S-Glutarimide-amide-Py-piperidine-CHO-生命科学试剂-MCE.pdfVIP

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(S)-Glutarimide-amide-Py-piperidine-CHO

Cat.No.:HY-49390

CASNo.:2649400-06-4

分⼦式:C₁₇H₂₀N₄O₄

分⼦量:344.37

作⽤靶点:E3LigaseLigand-LinkerConjugates

作⽤通路:PROTAC

储存⽅式:4°C,protectfromlight,storedundernitrogen

*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)

BIOLOGICALACTIVITY

⽣物活性(S)-Glutarimide-amide-Py-piperidine-CHO是⼀种E3连接酶配体-linker偶联物，包含基于CRBN的配体和

linker，可⽤于合成PROTAC。

IC50TargetCereblon

体外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseand

theotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto

selectivelydegradetargetproteins.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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