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SodiumCitrateCHCOONa

2

TrisodiumCitrate|

HO-C-COONa

|

CHCOONa

2

CHNaO,2H0294.16132-04-2

65372

Sodiumcitratecomplieswithrequirementsofthe3rdeditionoftheEuropeanpharmacopoeia

〔0412〕.theserequirementsarereproducedaftertheheading‘Definition’below.

Actionandusesystemicalkalinizingsubstance.

Preparations

SodiumcitrateEyeDrops

Sodiumcitrateirrigationsolution

SodiumcitrateTablers

PhEur

DEFINITION

oftrisodium2-hydroxypropane–1,2,3-tricarboxylate,calculatedwithreferencetotheanhydrous

substance.

CHARACTERS

A

inwater,practicallyinsolubleinalcohol.

IDENTIFICATION

A.

(2.3.1)

B.1mlofsolutionSgivesreaction(a)ofsodium(2.3.1)

TESTS

SolutionSDissolve10.0gincarbondioxide-freewaterRpreparedfromdistilledwaterRand

diluteto100mlwiththesamesolvent.

AppearanceofsolutionSisclear(2.2.1)andcolourless(methodⅡ2.2.2).

Acidityoralkalinityto10mlofsolutionSadd0.1mlofphenolphthalcinsolutionR.notmore

than0.2mlof0.1Mhydrochloricacidor0.1Msodiumhydroxideisrequiredtochangethecolour

oftheindicator.

ReadilycarbonisablesubstanceTo0.20gofthepoweredsubstancetobeexaminedadd10mlof

sulphuricacidRandheatinawater-bathat90+/-1℃for60min.coolrapidly.Thesolutionisnot

moreintenselycolouredthanreferencesolutionY2orGY2(MethodⅡ,2.2.2)

Chlorides

limittestforchlorides(50ppm)

OxalatesDissolvegin4mlofwaterR,add3mlofhydrochlorigacidRand1gofgradulated

zincRandheatonawater-bathfor1min.allowtostandfor2min,decant