Ginsenoside-C-K-hexapropionate-ester-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

GinsenosideC-Khexapropionateester

Cat.No.:HY-185104

CASNo.:2861254-89-7

分⼦式:C₅₄H₈₆O₁₄

分⼦量:959.25

作⽤靶点:LXR

作⽤通路:MetabolicEnzyme/Protease;VitaminDRelated/Nuclear

Receptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性GinsenosideC-Khexapropionateester(Structure2)是LXRα的选择性激动剂，对LXRβ⽆显著激活作⽤。

GinsenosideC-Khexapropionateester通过激活LXRα上调ABCA1等下游基因表达，促进胆固醇逆向转运

，减少巨噬细胞来源泡沫细胞的脂质沉积，可⽤于动脉粥样硬化的研究。GinsenosideC-Khexapropionate

ester是以三七(Panaxnotoginseng)皂苷的活性代谢产物⼈参皂苷CompoundK为原料，经丙酸酐修饰合成

的衍⽣物。

IC50TargetLXRα

REFERENCES

[1].HuangY,etal.SynthesisandBiologicalEvaluationofGinsenosideCompoundKDerivativesasaNovelClassofLXRαActivator.

Molecules.2017Jul24;22(7):1232.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:02