Lys-PEG1-Dasa-生命科学试剂-MCE.pdfVIP

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Lys-PEG1-Dasa

Cat.No.:HY-180963

分⼦式:C₃₃H₄₇ClN₁₀O₅S

分⼦量:731.31

作⽤靶点:PROTACs;Bcr-Abl

作⽤通路:PROTAC;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Lys-PEG1-Dasa是⼀种靶向BCR-ABL的PROTAC降解剂，其在K562细胞中的DC50为0.98nM。Lys-PEG1-

Dasa对K562细胞具有增殖抑制活性，对应的IC50为0.4569nM。Lys-PEG1-Dasa可⽤于慢性粒细胞⽩⾎病

的相关研究[1][2]。

体外研究Lys-PEG1-Dasa(0-2.5nM,0-48h)efficientlydownregulatesBCR-ABLandexertspotentantiproliferative

activityinK562cells[1].

CellCytotoxicityAssay[1]

CellLine:K562cells

Concentration:0,0.01,0.1,0.25,0.5,0.75,1and2.5nM

IncubationTime:48h

Result:ExertedpotentantiproliferativeactivitywithIC50=0.4569nM

WesternBlotAnalysis[1]

CellLine:K562cells

Concentration:0,0.5,1,2.5and5nM

IncubationTime:0,12,24,36and48h

Result:EfficientlydownregulatedBCR-ABLproteinexpressionwithDC50=0.4790nM,Dmax

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