Ro-25-1553-TFA-生命科学试剂-MCE.pdfVIP

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Ro25-1553TFA

Cat.No.:HY-P10768A

分⼦式:C₁₆₀H₂₅₈N₄₆O₄₆·xC₂HF₃O₂

Sequence:Ac-His-Ser-Asp-Ala-Val-Phe-Thr-Glu-Asn-Tyr-Thr-Lys-Leu-Arg

-Lys-Gln-{Nle}-Ala-Ala-Lys-Lys-Tyr-Leu-Asn-Asp-Leu-Lys-Lys-

Gly-Gly-Thr-NH2(Lactambridge:Lys21-Asp25)

SequenceShortening:Ac-HSDAVFTENYTKLRKQ-{Nle}-AAKKYLNDLKKGGT-NH2

(Lactambridge:Lys21-Asp25)

作⽤靶点:PACAPReceptor

作⽤通路:GPCR/GProtein

储存⽅式:Sealedstorage,awayfrommoisture

Powder-80°C2years

-20°C1year

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性Ro25-1553TFA是⼀种31个氨基酸组成的⾎管活性肠肽(VIP)类似物，可作为VIP2受体(VPAC2receptor)的

激动剂。Ro25-1553TFA在豚⿏模型中表现出对神经诱发或Carbachol(HY-B1208)诱发的⽓管平滑肌收缩的

⽀⽓管扩张作⽤[1]。

IC50TargetVPAC2receptor

REFERENCES

[1].KällströmBL,etal.,BronchodilatingpropertiesoftheVIPreceptoragonistRo25-1553comparedtothoseofformoterolontheguinea-

pigisolatedtrachea.Eur