涎腺肿瘤-上交大《口腔组织病理学》精品课.pptVIP

Salivary Gland Tumors(涎腺肿瘤) Introduction (1) One of the characteristic tumors of the maxillofacial region Likely the most complex histopathology of any organ Wide spectrum of different tumor types Introduction (2) Currently the 1991 edition(2nd) WHO classification published 3rd edition(2005), add some new types Histological Typing of Salivary Gland Tumors (WHO 1991) 1. pleomorphic adenoma（多形性腺瘤） 2. myoepithelioma 3. basal cell adenoma（基底细胞腺瘤） 4. Warthin tumor （腺淋巴瘤） 5. oncocytoma 6. canalicular adenoma 7. sebaceous adenoma 8. ductal papilloma 9. cystadenoma Carcinomas (癌)(1) acinic cell carcinoma （腺泡细胞癌） mucoepidermoid carcinoma （黏液表皮样癌） adenoid cystic carcinoma（腺样囊性癌） polymorphous low grade adenocarcinoma epithelial-myoepithelial carcinoma basal cell adenocarcinoma sebaceous carcinoma papillary cystadenocarcinoma mucinous adenocarcinoma Carcinomas (2) oncocytic carcinoma salivary duct carcinoma adenocarcinoma myoepithelial carcinoma carcinoma in pleomorphic adenoma squamous cell carcinoma small cell carcinoma undifferentiated carcinoma other carcinoma Benign Neoplasms（良性肿瘤） Pleomorphic Adenoma(Mixed Tumor) (多形性腺瘤) Pleomorphic AdenomaIntroduction The commonest salivary gland tumor China 87% benign, epithelial tumors of salivary gland Pleomorphic AdenomaClinical Features（临床特征） Age Wide age range From 1st to 10th decades Peak: 3rd to 4th decades Gender Slight female predominance Pleomorphic AdenomaClinical Features Site Major gland (大涎腺) Parotid（腮腺） Submandibular Sublingual (63.4%) (9.5%) (0.1%) Minor gland (小涎腺) Palate（腭）, Lip, Cheek, Tongue (10.3%) (4.3%) (1.8%) (0.2%) (AFIP) Pleomorphic AdenomaClinical Features Painless, slow growing mass Usually 2-6 cm in diameter Neglected tumor has grown to over 30 cm Solitary, round, well circumscribed（界限）, with a smooth surface Pleomorphic AdenomaClinical Features Major g