合作课题与NIH申请书的书写.pptVIP

合作课题与NIH申请书的书写 合作课题申请： 课题分担：课题承担量大，需多实验室合作； 研究资源互补：人力资源、现场资源或动物资源优势与技术资源互补； 研究能力互补：细胞学、分子生物学、新型技术与实验方法 Significance: The CIPRA cohort offers a unique population infected at about the same time with a uniform HIV strain. Determining immunologic parameters that differentiate progression of disease from non-progression can be quite significant. Approach: This application from a group of investigators in China aims to evaluate two cohorts of HIV infected patients from the CIPRA project to determine functionality of CD8 epitope-specific immune responses during HIV-1 infection and correlate these with progression or containment of HIV replication. This cohort contains patients who were infected with HIV about 10 years ago through contaminated blood products. All were infected by the Thailand B virus. Innovation: The study of CD8 responses to specific viral epitopes and correlation with Treg function in progressor vs. non-progressor populations is innovative. Grant Application: Five components from each reviewer Investigators: The PI, Dr. Xu, is experienced in HIV immunology research. His research team has relevant experience in biostatistics and molecular virology; however, the responsibilities of each team member are not described. Environment: The PI’s laboratory is well equipped to carry out the proposed work. Clinical resources critical to the project are demonstrated in the preliminary Data, but apparently are quite distant from the laboratory, requiring delivery of specimens by aircraft, which may be problematic. Five components from each reviewer Innovation: The study of CD8 responses to specific viral epitopes and correlation with Treg function in progressor vs. non-progressor populations is innovative. Innovation: The proposed project will address a critical barrier to progress in the field. After more than 20 years we still do not completely understand the immunopathogenesis of HIV infection. It is thought that information gained by comparing immune, viral, a