报告同学.pptVIP

WNT and beta-catenin signalling: diseases and therapies. Nat. Rev. Genet. 5, 691-701 (2004) 報告同學: 陳宜芳 組 員: 陳宜芳 陳彥任 葉儀君 莊健盈 王怡婷 黃冠誠 林佩儒 邱敏熙 楊瑞珠 楊玫琳 曾宜萱 徐袁章 Wnt signalling pathway Altered function of Frizzled and LRP5/6 Loss-of-function mutations in FZ4 and LRP5 are linked to familial exudative vitreoretinopathy (FEVR) a truncated protein that acts in a dominant– negative manner ? oligomerize with wild-type FZ receptors ? trap them in the endoplasmic reticulum Whether FZ4 signalling is reduced in FEVR patients? Altered function of Fri