混合时滞基因调控网络的自适应稳定化研究.docVIP

混合时滞基因调控网络的自适应稳定化研究 胡建强，梁金玲 东南大学数学系，南京 210096 摘要：本文研究了一类具有混合时滞的基因调控网络的稳定化问题，这里混合时滞既包括有限 分布时滞亦包括离散时滞。在自适应反馈控制输入策略下，分析了基因调控网络的全局渐近稳 定性。通过适当分割积分区间以及离散时滞，构建相应的 Lyapunov-Krasovskii 泛函，给出了 若干以线性矩阵不等式形式表述的充分判据。最后，通过一个数值仿真实例进一步说明了所得 理论结果不仅是有效的，而且具有较低的保守性。 关键词：基因调控网络；自适应控制；积分分割技巧；时滞分割法；混合时滞 中图分类号： O231.2 Adaptive Stabilization for Genetic Regulatory Networks with Mixed Delays HU Jian-Qiang, LIANG Jin-Ling Department of Mathematics, Southeast University, Nanjing 210096 Abstract: In this paper, the stabilization of a class of mixed delayed genetic regulatory networks (GRNs) is investigated. The adaptive feedback control scheme is used to achieve global asymptotic stability for the GRNs with ?nite distributed delays and discrete delays. By introducing the integral partitioning technique and delay fractioning approach, a Lyapunov-Krasovskii function (LKF) is constructed, and some su?cient stability criteria in the form of LMIs are established. Finally, a numerical example is given to illustrate the e?ectiveness of our theoretical results and less conservativeness of the proposed method. Key words: Genetic regulatory networks; Adaptive control; Integral partitioning technique; Delay fractioning approach; Mixed delays. 0 Introduction Networks of interacting biomolecules exert many essential functions in the cells of living organisms, one of the most in?uential interactions is the genetic networks which are very helpful for our understanding genome sequencing and gene recognition. The seminal works on genetic networks portrayed by di?erential equation models [1] have triggered a ?urry of activities 基金项目： The Specialized Research Fund for the Doctoral Program of Higher Education for New Teachers in China (200802861044) 作者简介： Hu Jianqiang (1988-), male, master student, major research direction: genetic regulatory networks. Cor- respondence author：Liang Jinling (1974-), female, associate professor, major research direction：complex networks, delay systems, robust control. -1- [2, 3,