无机载银抗菌材料抗菌机理及细菌对其抗性机制.pdfVIP

材料导报网刊 2008 年1 月第1 期 ·20 · 无机载银抗菌材料抗菌机理及细菌对其抗性机制 李文茹，谢小保 ，欧阳友生， 陈仪本 (广东省微生物研究所，广东省菌种保藏与应用重点实验室， 广州 510070) 摘要 无机载银抗菌材料具有广谱高效的抗菌性能，并得到了广泛应用，对其抗菌机理及细菌对其抗性机制进行了综述。 银离子从无机物载体中缓慢释放，当微量 Ag+ 到达微生物细胞膜时，主要通过破坏微生物膜上与呼吸产能相关的电子传输 系统、物质传送系统或其他与细胞代谢活动相关的蛋白或酶的活性，致使菌体细胞死亡或被抑制。同时，在长期的环境适应 条件下，很多细菌产生了对Ag+ 的抗性，这种抗性与细菌对银的有效外排，周质空间对银的吸收和外膜缺失孔道等机制有关。 对无机载银抗菌材料的抗菌机制以及细菌的抗银机制进行了泛深入的研究，将为开发更加广谱高效的抗菌材料提供理论基 础。 关键词 无机载银抗菌材料 抗菌机理 抗性机制 Advance in Antimicrobial Mechanism of Silver-Carrying Inorganic Antimicrobial Materials and Silver-Resistance Mechanism of Microbe LI Wenru ，XIE Xiaobao ，OUYANG Yousheng ，CHEN Yiben (Guangdong Institute of Microbiology,，Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangzhou, 510070) Abstract Silver-carrying inorganic antimicrobial materials are used extensively in many industries, which have promising development prospect. Silver ions are released slowly from silver-carring inorganic antimicrobial materials. When micro-silver ions penetrate the cell membrane, they may inhibit or kill microorganisms mainly by destroying electron transfer chain, materials transfer system and the activities of proteins or enzymes correlative with cell metabolism located in cell membrane. Furthermore, for conforming to environment many bacterium develop a resistance mechanism to silver-carring inorganic antimicrobial materials. The resistance mechanism is associated with silver expelling from cell, silver absorbed by periplasm and cell losing channel to silvers. The extensive and in-depth studies about the antimicrobial mechanism of silver-carrying inorganic antimicrobial materials and the silver resistance mechanism of bacteria will provide a