液基細胞學於診斷宮頸上皮內瘤樣病變的價值.pdfVIP

暨南大學碩士學位論文 液基細胞學於診斷宮頸上皮內瘤樣病變的價值 _____________________________________________________________________________________________ Value of ThinPrep Cytology technology as the screening approach for cervical intraepithelial neoplasia Author name: CHEUNG WU, POLLIY Tutor name: Professor WEN, Wang Rong ABSTRACT Background Atypical squamous cells of undetermined significance (ASC-US) has been widely accepted as the precursor of cervical carcinoma development. Female patients diagnosed with ASC-US should be monitored by using a program of either repeat cervical cytology testing, immediate colposcopy or DNA testing for high-risk types of human papillomavirus (HPV) which is proved to be closely related to cervical carcinoma as one of the major causes. Nowadays, to test for HPV DNA, liquid-based cytology is the preferred approach for women participating the screening program. Patients with positive result of HR HPV DNA should be referred for colposcopic evaluation; if ASC-US found with negative detection of HR HPV DNA result, patients are suggested to have repeat cytologic testing in 12 months to monitor for any further lesion development. The technique of detecting the HR HPV DNA can indicate patients may be infected with one or more of the following HR HPV DNA genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68 which are associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should always be correlated with cytologic / histologic findings. I 暨南大學碩士學位論文 液基細胞學於診斷宮頸上皮內瘤樣病變的價值 _________________________