铁过载的危害.pptVIP

1.人体内的铁是通过转铁蛋白来转运的，当转铁蛋白几乎完全饱和时 ，血浆内会出现非转铁蛋白结合铁(NTBI) 2.非转铁蛋白结合铁(NTBI)可以沉积在组织及器官上，形成非结合不稳定铁(LPI) , 促进有害的活性氧自由基(ROS)形成，是造成铁过载并发症的主要原因 * In patients who are iron-overloaded the capacity of serum transferrin to bind iron may be exceeded, which means that NTBI may circulate in the plasma. This unbound iron, which is carried in the iron storage protein ferritin, can promote the generation of free hydroxyl radicals, which propagate oxygen-related tissue damage. Additionally, insoluble iron complexes called hemosiderins may become deposited in body tissues causing toxicity and death. Cardiac failure