乳腺发育及泌乳相关miRNA研究进展.pdfVIP

HEREDITAS (Beijing) 2013 6 , 35(6): 695―702 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2013.00695 乳腺发育及泌乳相关miRNA 研究进展 金晓露, 杨建香, 李真, 刘红云, 刘建新 , 310058 MicroRNA(miRNA)是一种重要的转录后调控的非编码RNA, 参与调控哺乳动物乳腺发育和泌乳。文章 总结了乳腺发育和泌乳过程中miRNA 表达的时空特异性, 综述了个别miRNA 对乳腺发育和泌乳的调节作用, 旨在 为乳腺miRNA 的研究提供指导, 为利用miRNA 促进乳腺健康发育和调控高质高效产乳提供理论基础和研究思路。 miRNA; 乳腺发育; 泌乳 Progress on the miRNA related with mammary gland development and lactation JIN Xiao-Lu, YANG Jian-Xiang, LI Zhen, LIU Hong-Yun, LIU Jian-Xin Institute of Dairy Science , College of Animal Science, Zhejiang University, Hangzhou 310058, China Abstract: MicroRNAs (miRNAs) are non-coding RNAs that play important roles in post transcriptional regulation. They are involved in the regulation of mammary gland development and lactation. In this paper, we summarized the expres- sion pattern of miRNAs which varied with tissues and lactation stages, and the functions of several miRNAs are also briefly reviewed. The objective of this work is to give reference for further study on miRNAs in mammary gland, and to provide theoretical basis and ideas for the use of miRNAs in improving healthy development of mammary gland and regulating the efficiency of lactation and the quality of milk. Keywords: miRNA; mammary gland development; lactation 1993 lin-4 let- miRNA [1~3] 7, , miRNA MicroRNA(miRNA) miRNA miRNA ; miRNA , ; miRNA [4], miRNA 收稿日期: 2012−10−20; 修回日期: 2012−12−30 基金项目: (973