电纺技术在生物医学中的应用进展.pdfVIP

第21卷 第4期 生命科学 Vol. 21, No. 4 2009年8月 Chinese Bulletin of Life Sciences Aug., 2009 文章编号 ：1004-0374(2009)04-0599-07 电纺技术在生物医学中的应用进展 吴易潘，李新新，冯喜增 * (南开大学生命科学学院，生物活性材料教育部重点实验室，天津300071) 摘　要：电纺技术已经成为结合多组分化合物与织造技术的关键工具，可改变电纺丝材料的化学、物 理和生物特性，使其与不同的应用环境相适应。通过电纺技术制作的功能化纳米电纺丝材料，在组织 工程、创伤敷料、酶的固定化和药物(基因)载体等生物医学方面得到了广泛的应用。新型的电纺技术 可以进一步优化纳米电纺丝的特性，如同轴电纺、二相电纺技术；电纺丝膜的修饰也为调控电纺丝的 各向异性和多孔性提供了有效的方法。该文将概述功能化电纺丝的纺织技术及修饰方法在生物医学领域 的研究与应用进展。 关键词： 电纺技术；纳米纤维；修饰；生物医学应用 中图分类号：N39; TB383　　文献标识码：A Electrospun technique for biomedical applications WU Yi-pan, LI Xin-xin, FENG Xi-zeng* (The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China) Abstract：Electrospun technique has become the pivotal tool, which is a combination of multi-component compositions and fabrication techniques. The chemical, physical and biological properties of electrospun scaf- folds can be adjusted by the fabrication techniques to match the different environment that the scaffolds applied in. Functional nanofibrous scaffolds produced by electrospinning have great potential in many biomedical applications, such as tissue engineering, wound dressing, enzyme immobilization and drug (gene) delivery. The property of the nanofibrous scaffold can be further improved with innovative development in electrospinning processes, such as coaxial electrospinning and two-component electrospinning. Post modifica- tions of electrospun membranes also provide effective means to render the electrospun scaffolds with con- trolled anisotropy and porosity. In this article, we will review the techniques and po