同种T细胞识别机制与潜在应用价值.pptVIP

Figure 2. The dimer-expanded CD8lowCD28- T cells exhibit suppressive effects on alloreactive T cells. (A) A negative correlation between CD8lowCD28- and IFN-γ-expressing T cells was observed using curve estimation and linear regression analyses in the alloreactive coculture of HLA-2-ve PBLs and T2/Tyr with (dimer treated) and without (non-dimer treated) the Tyr/HLA-A2 dimer. Correlation coefficients and p values are shown for each analysis (n=15). (B) The dimer-expanded CD8lowCD28- T cells showed suppressive effects on alloreactive T cells. The T2/Tyr-primed CD8high and the Tyr/HLA-A2 dimer-e