非肥満非アルコール性脂肪性肝疾患患者の栄養学的研究―食事性コレステロールの重要性と薬物療法への展開―.pdfVIP

, 842 - 8585 4490 - 9 Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: The significance of dietary cholesterol and the application to medication Kenichiro Yasutake Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, 4490 - 9 Kanzaki Saga 842 - 8585 , Japan. Abstract The onset and progression of non-alcoholic fatty liver disease (NAFLD) seem to be affected by nutritive intake; however, detailed examinations have not been performed in non-obese NAFLD patients. The purpose of this study was to identify potential nutritive factors that affect NAFLD, its related nutritional problems and the application to medication. We investigated the distribution of abdominal fat, dietary intake, and biochemical data in patients with NAFLD and compared non-obese with obese patients. There was no significant difference in the percent age of p atient s with diabete s or dy slipidemia between the obe se and non -obe se gr oup s. Wai st circumference, total abdominal fat levels, and subcutaneous fat levels were significantly higher in the obese group, while visceral fat levels were not significantly different between the two groups. Immunoreactive insulin (IRI) and homeostasis model assessment-insulin resistance (HOMA-IR) were significantly lower in the non-obese group, suggesting that the non-obese patients were not overtly insulin resistant. Although serum adiponectin and TNF-a levels were similar in both groups, leptin levels were significantly higher in the obese group. Total energy and carbohydrate intake tended to be higher in the obese group . A characteristic feature was that dietary cholesterol intake was significantly higher in th