P21活化激酶在神经系统中的作用.pdfVIP

700 生理学报Acta Physiologica Sinica , December 25, 2012, 64(6): 700–706 综 述 P21活化激酶在神经系统中的作用 1 1,2,* 1 秦 园，丁悦敏 ，夏强 1 310058 2 310015 浙江大学医学院生理学系，杭州 ；浙江大学城市学院医学院，杭州 P21 (P21-activated kinases, PAK) 摘 要： 活化激酶 参与多种重要的细胞生命活动，如细胞骨架重构、细胞迁移、细胞周期调控 PAK 以及细胞的凋亡或生存。在神经系统中， 可能与大脑发育、神经细胞分化、突触可塑性调节等生理过程有密切关系。 PAK 的异常会导致诸如肿瘤、帕金森病(Parkinson’s disease, PD)、阿尔茨海默病(Alzheimer’s disease, AD)、神经发育迟缓等疾 PAK 病。因此，研究 在神经系统中的功能具有十分重要的生理学意义。本文对这一蛋白激酶家族在神经系统中的生物学功 能及其机制的研究进展作一综述。 P21 关键词： 活化激酶；神经系统；疾病 中图分类号：R338.2 P21-activated kinases and their role in the nervous system 1 1,2,* 1 QIN Yuan , DING Yue-Min , XIA Qiang 1Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310058, China; 2 Medical School, Zhejiang University City College, Hangzhou 310015, China Abstract: P21-activated kinases (PAK) participate in a variety of important cellular activities, such as cytoskeleton remodeling, cell migration, cell cycle regulation, and apoptosis or survival. PAK also has an important impact on brain development, neuronal differen- tiation, and regulation of synaptic plasticity in the nervous system. PAK abnormalities result in diseases including cancer, Parkinson’s disease (PD), Alzheimer’s disease (AD) and neural retardation. Therefore, it is of vital physiological significance to investigate the neuronal function of PAK. In this paper we review the advancement of research on the neuronal biological function and the underlying mechanisms of PAK. Key words: P21-activated kinases; nervous system; diseases P21 活化激酶(P21-activated kinases, PAK) 是Rho- 架重构、细胞迁移、细胞周期调