放疗联合TP方案化疗综合治疗食管癌100例临床分析.pdfVIP

· 2378 · M0DERN 0NC0L0GY．Dec．2010．V0I．18．N0．12 ficienciesoffolateandvitamineB一6arecommonandvarywith seaso~inChinesewomenofchildbearingage[J]．JNutr，2000， (编校 ：田媛) 放疗联合TP方案化疗综合治疗食管癌 100例临床分析 万志龙，葛 琴，成国建，杭达明，朱琪伟，季秀珍 ClinicalanalysisofradiationtherapycombinedwithTPchemotherapyforesophageal cancer WANZhi—long，GEQin，CHENGGuo—jian，HANGDa—ming，ZHUQi—wei，JIXiu—zhen DepartmentofRadiotherapy，NantongTumorHospital，JiangsuNantong226361，China． 【Abstract】 0bjeefive：ToevaluatethefeasibilityandefficacyofradiationtherapycombinedwithTPchemotherapy foresophagealcancer．Methods：Total of200 advanced esophageal carcinomapatientswererandomizedintotwo groups．100 patientsincombinedgroupreceivedchemoradiotherapy：paclitaxel135mg／m ，dl；DDP30mg／m ，d1 — 3 ， andreceivedradiotherapyaweeklater．Allpatientswereirradiated2Gyper~action，fivefractionsaweek．血etotal dosewas60—70Gy／6—7w．Results：Theclinicalimprovementin山ecombinedgroupwas88％ and68．0％ inthe radiotherapyonlyrgoup(P0．05)．Short—term effectinthecomb inedgroupWas89．1％ nad67．O％ intheradio— therapyonlygroup(P0．05、．Theacutetoxiceffectwassevrcincomb inedrgoupthaninradiohterapyonlyrgoup． e1，2，3一yearsurvivalratewere63％ ，50％ ，39％ inthecombinedgroup，and54％ ，42％ ，30％ intheradiothera- PYonlyrgoup，(P0．05)．Conclusion：TheresultofradiohterapycombinedTPchemohterapywasmoreeffective thanradiotherapyaloneinthetreatmentofesophageal cancer． 【Keywords】esophagealcancer；radiotherapy；chemohterapy；efficacy ModernOncology2010，18(12)：2378—2379 【摘要】 目的：探讨食管癌放疗加TP方案化疗综合治疗的可行性和近期疗效。方法：200例诊断为中晚期 食道癌患者随机分组，综合治疗组应用放疗加化疗 100例：紫杉醇 135rag／m 静滴，d，DDP30mg／m ，静滴， d 一 ， ，休息1周后采用6MVX射线常规分割，前后