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中国医学影像技术2004 年第 20 卷第 3 期 Chin J Med Imaging Technol ,2004 ,Vol 20 ,No 3 4·55 ·
Regional brain glucose metabolism change in cancer patients by SPM
YUAN Zhibin , Matsubara K , Higuchi T , Oriuchi N , Endo K
( Department of Nuclear Medicine , Shanghai Jiaotong University , Shanghai 6 th People ’s Hospital ,
)
Shanghai 200233 , China
18
[ Abstract] Objective To investigate the change of regional brain glucose metabolism in cancer patients by FFDG
18F
PET imaging. Methods FDGPET was performed on 20 patients with various types of cancer and 20 cases of age
and gender matched normal volunteers for comparison by using Shimadzu SET 2400 PET scanner. All the patients and
18F
control cases were absence of clear focal brain lesions , moderate to severe pain and neurological symptoms. The brain
FDGPET images were analyzed and compared by statistical parametric mapping ( SPM) . Results Significant glucose
metabolic reduction was detected in the area of prefrontal cortex , allosal gyrus cortex , parietal lobe cortex , temporal
lobe cortex , insula , limbic system , cerebellum and corpus striatum. These findings were accordance with the known le
sions of major depression and similar to the reported literature. Conclusion It could be concluded that the psychologi
cal deficits in can
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