低毒溶致液晶的构建及做姜黄素载体的研究.pdfVIP

※基础研究 食品科学 2013, Vol.34, No.01 13 王仲妮，汤晓露，周 武，郭富民，李 振，赵 静 ( 山东师范大学化学化工与材料科学学院，农药医药中间体清洁生产教育部工程技术中心，山东 济南 250014) 摘 要：测定25 ℃条件下油烯基聚氧乙烯(20)醚在乙酸丁酯/水介质中的相图，探讨生物表面活性剂脱氧胆酸钠 (NaDC)对体系相行为和流变性质的影响。进一步对上述体系所形成的溶致液晶进行对姜黄素的保护和体外释放研 究。结果表明：体系中存在六角相和立方相，加入NaDC后六角相缩小，立方相消失。这些溶致液晶相在稳态剪切 条件下均表现为剪切稀释的性质；但立方状液晶表现出较突出的弹性性质，表现在tan δ＜0.1 ，而六角状液晶表现 典型的黏弹性性质(tan δ为0.47～0.54)，而且加入NaDC使六角状液晶的特征松弛时间增大。在光照下溶致液晶对姜 黄素有保护作用，加入NaDC可使保护作用增强。这些液晶相对姜黄素有一定的缓释效果，NaDC 的加入延长了其 释放到达平衡所需要的时间，增强缓释效果。 ：溶致液晶；姜黄素；流变性质；脱氧胆酸钠；载体 Construction of Lowly Toxic Liquid Crystals as Curcumin Delivery System WANG Zhong-ni ，TANG Xiao-lu，ZHOU Wu ，GUO Fu-min，LI Zhen ，ZHAO Jing (Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Ji ’nan 250014, China) Abstract ：The phase diagram of oleyl polyoxyethylene (20) ether/butyl acetate/water was determined at 25 ℃, and the infl uence of the biosurfactant sodium deoxycholate (NaDC) on the phase behavior and rheological properties of the system was investigated. Furthermore, the protection and in vitro release behavior of curcumin in the liquid crystals were studied. Hexagonal and cubic crystals were found in the ternary system. When adding NaDC, the area of hexagonal phase became smaller and the cubic phase disappeared. All investigated samples followed a shear-thinning behavior under steady shear. The cubic crystals showed high elasticity with tan δvalues less than 0.1, while the hexagonal crystals demonstrated typical visco-elasticity with tan δ values between 0.47 and 0.54. The characteristic relaxation time of the hexagonal crystals increased afte