牛乳铁蛋白肽的研究现状与应用前景.pdfVIP

※专题论述 食品科学 2011, Vol. 32, No. 13 369 李忠清1,2,3 ，王 亮 1,3,* (1. 中国科学院新疆理化技术研究所，新疆 乌鲁木齐 830011 ； 2.新疆金牛生物有限公司，新疆 乌鲁木齐 830026) ；3. 中国科学院研究生院，北京 100039) 牛乳铁蛋白肽是牛乳铁蛋白在胃蛋白酶水解作用下释放出的一种含 25 个氨基酸残基的短肽，具有广泛而 高效的抑菌活性，是一种新型的抗菌肽，在医药、食品添加剂乃至饲料业有着巨大的开发潜质。对其结构、理 化性质、生物学功能、作用机制及应用前景进行详细论述，并对乳铁蛋白肽的衍生肽的研究及策略进行探讨。 牛乳铁蛋白肽；抗菌肽；衍生肽 Current Status and Future Prospects of Bovine Lactoferricin LI Zhong-qing1,2,3 ，WANG Liang1,3,* .. .. (1. Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China；2. Xinjiang . . .. Jinniu Biology Co. Ltd., Urumqi 830026, China ；3. Graduate University, Chinese Academy of Sciences, Beijing 100039, China) Abstract ：Bovine lactoferricin (LfcinB) is a 25-residue peptide with highly effective, broad-spectrum antimicrobial generated by pepsin digestion of bovine lactoferin. LfcinB has revealed huge potential in the medicinal, food additive, and feed industries as a new type of antimicrobial peptide. This review presents its important structural features, physicochemical properties, biological function, mechanism of action and future prospects in detail. In addition, the recent advances in the research on its derivatives are also summarized. Key words ：LfcinB ；antibacterial peptide ；derivative 中图分类号：TS201.21 文献标识码：A 文章编号：1002-6630(2011)13-0369-05 [1] 乳铁蛋白是 Grov