GCSF与GMCSF联合用药治疗化疗后骨髓抑制的比较.pdfVIP

·146· G—CSF与GM—CSF联合用药治疗化疗后 骨髓抑制的比较 谷焰，郑 玲，伍建蓉，王晓毓，张鸿彬，朱俊臣，姜佳明 betweenCombinationofG-CSFandGM-CSFinPatientsWithArrestofBone Comparison Caused MarrowbyChemotherapy GUYan，ZHENG Xiao-yu，ZHANGHong-bin，ZHUJun-chen，JIANG Ling，WUJian-rong，WANG Jia-ming RailCentral 610081，China DepastmentofOncology，ChengduHospital，Chengdu To the andadversereactionofcombinationofG-CSF safety，feasibility Abstract：Objectiveinvestigate in andabovearrestofbonemarrowcaused andGM-CSF withⅡdegree bychemotherapy．Meth— patients ods84 withdeftnite tumorand andabovearrestofbonemarrowcaused patients malignant IIdegree by wereenrolledintoa andrandom chemotherapy single-blindedstudy：G-CSFgroup(Ggroup，n=28，G- CSF subcutaneous 150 subcu— 150}tg／d injection)，GM-CSF：group(GMgroup：n=28，GM-CSFFtg／d taneous andGM-CSF injection)，combinationdrugsgroup(G／GMgroup，n=28，G-CSF75／ig／d 75／zg／d ofWBCnormalizationafterCSF subcutaneous items：(1)the injection)．Observationdays application； of countafter48hourswithdrawalof (2)WBCcountafter48hourswithdrawalCSF；(3)PLT CSF；(4) of countinthree increased．Theof incidencerate adversereaction．Results Leukcocyte groups days normalizationinGM were thanthatinG and WBC group longer groupG／GMgroup(P0．05)．WBC after48hourswithdrawalofCSFinGM and was morethanthatin count groupG／GMgroupobviously G rateofadversereactioninthree was andtherewasno group(P0．05