电刺激下丘脑乳头体及其周围区域调节家兔血压的观测.pdfVIP

中国科技论文在线 电刺激下丘脑乳头体及其周围区域调节家 兔血压的观测# ** 田若渝，李毅翔，朱罗娜，李世平，衡斌，刘燕强 5 （南开大学生命科学学院，天津 300071） 摘要：目的：探究下丘脑乳头体核及其周围核团对动脉血压的调节作用。方法：以家兔为实 验动物，按Sawyer 图谱对家兔下丘脑乳头体立体定位，分别给予下丘脑乳头体核及其周围 核团连续电刺激，观测家兔动脉血压的变化趋势。结果：电刺激乳头体，家兔动脉血压成强 度依赖性血压升高；电刺激乳头体外侧、上侧、前和后侧1mm 处，家兔动脉血压均下降， 10 而电刺激乳头体下侧，家兔动脉血压像刺激乳头体一样血压升高；电刺激乳头体上方2 mm 处家兔血压仍成强度依赖性下降，而电刺激乳头体下方超过2mm 处家兔动脉血压未见变化。 结论：上述结果提示，乳头体核与其周围核团在调节血压上功能是不同的，乳头体核可能是 交感神经兴奋性调节中枢的核团，而其周围则可能存在调节副交感兴奋的众多核团。 关键词：动物生理学；脑立体定位；下丘脑；乳头体核；动脉血压 15 中图分类号：Q955 Investigation of arterial blood pressure in rabbit regulated by stimulating electrically the mammlary body and surroundings areas 20 TIAN Ruoyu, LI Yixiang, ZHU Luona, LI Shiping, HENG Bin, LIU Yanqiang (College of Life Sciences, Nankai University, TianJin 300071) Abstract: Objective: To investigate the role of mammillary body and its surrounding areas of hypothalamus in regulating arterial blood pressure. Methods:, The mammillary body of rabbit was accurately located by stereotaxic apparatus according to Sawyer’s map. And the change of arterial 25 blood pressure in rabbit was recorded because of the mammillary body and its surrounding areas of hypothalamus given by continuous electrical stimulation. Results: Current intensity-dependent increase of arterial blood pressure in rabbit resulted from stimulating electrically the mammillary body. Stimulating outside, upward, anterior and rearward 1mm pla