基于分段预测模型的改进血糖控制.pdfVIP

中国科技论文在线 基于分段预测模型的改进血糖控制# 王友清，孙慧玲，闫朝峰* （北京化工大学信息科学与技术学院，北京 100029） 5 摘要：鉴于糖尿病的发病率及对人身体缓慢并严重的影响，人们对于糖尿病的关注度越来越 高。随着科学技术的发展，糖尿病的治疗方法也逐日进步。持续皮下输注胰岛素泵和动态血 糖监测系统的出现使得人工胰脏成为可能。在人工胰脏中，使用单一模型进行控制的模型预 测控制器会将饮食作为干扰，饮食后的高血糖与低血糖很难同时避免。本文针对上述问题提 出了一种在进食后进行大剂量注射并更换模型的方法，并在仿真平台上对其进行了多次测 10 试，最终，这种方法将饮食后的血糖很好的控制在了合适范围内。 关键词：控制科学与工程；人工胰脏；1 型糖尿病；MPC 控制；分段预测模型 中图分类号：TP3 Improved Glycemic Control Based on Segmented Prediction 15 Models WANG Youqing, SUN Huiling, YAN Chaofeng (College of Information Science Technology, Beijing University of Chemical Technology, Beijing 100029) Abstract: As the increasing incidence of diabetes mellitus and its serious impact on human body, 20 people are paying more attention on it. Thanks to the development of science and technology, the treatment of diabetes gets daily progress. The appearance of continuous subcutaneous insulin infusion pumps and continuous glucose monitoring system makes the closed-loop control of artificial pancreas (AP) system feasible. However, the hypoglycemia and the hyperglycemia after big meals cannot be avoided at the same time under model predictive control with only one 25 prediction model. Aiming at sloving the above issue, the idea of injecting certain amount insulin bolus after the meal and changing the prediction model of the controller at the same time was used in this study. Through the simulation test, the proposed algorithm wa