熊去氧胆酸治疗肝内胆汁淤积症临床观察研究.pdfVIP

安 徽 医 药 AnhuiMedicalandPharmaceuticalJournal 2010Jul；14(7) ·827 · 熊去氧胆酸治疗肝内胆汁淤积症临床观察研究 许 镇，许建明，丁玮玮 (安徽医科大学第一附属医院,g4e内科，安徽 合肥 230022) 摘要：目的 对 比观察应用熊去氧胆酸(UDCA)治疗肝 内胆汁淤积症的疗效及安全性。方法 连续收集该院 199例肝 内胆汁 淤积患者，分为UDCA治疗组与常规保肝药对照组 ，比较二组治疗前后症状体征和肝生化指标的改善程度。结果 UDCA组显 效63例，有效48例 ，无效 26例 ，总有效率为 81．02％；对照组显效 18例，有效 24例，无效 20例，总有效率为 67．74％。熊去氧 胆酸能显著改善患者的肝功能生化指标 ，其中总胆红素 、结合胆红素、r一谷氨酰转移酶下降幅度高于对照组 (P0．05)。治疗观 察期间，两组均未见严重不 良反应。结论 熊去氧胆酸在对肝内胆汁淤积性肝病患者住院治疗期间疗效较满意，安全性 良好。 关键词 ：肝病；胆汁淤积；熊去氧胆酸 ClinicalstudyofursodeoxycholicacidOilpatientsofcholestasjs hepaticdiseases XU Zhen，XU Jian．ming．DINGWei—wei (DepartmentofGastroenterology，TheFirstAffiliatedHospitalofAnhuiMedicalUniversity，Hefei230022) Abstract：Aim Toevaluatetheefficacyandsafetyofursodeoxyeholicacidinthetreatmentofcholestasishepaticdiseaseswithcompari— sonstudy．Methods Onehundredandninty—ninepatientswithcholestasishepaticdiseasesweredividedintotheUDCA treatment groupandthecommonhepatoprotectivecontrolgroup．Improvementofsymptom signsandhepaticbiochemicalindicatorwerecompared beforeandafterthetreatment．Results Thereweresixty—threeexcellent，forty—eighteffective，andtwenty—sixineffectiveinUDCAgroup， withatotaleffectiverateof81．02％ ．Therewereeighteenexcellent，twenty—foureffective，andtwentyineffectiveincontrolrgoup．witha totaleffectiverateof67．74％．UDCAcouldsignificantlyimproveliverbiochemistry．Thedecreasesontotalbilirubin．conjugatedbilirubin andr—glutamyltransferaseinthetreatmentgroupweremuchhigherthanthoseinthecontrolgroup(P0．05)，buthad110effectonpru— ritusandSOon．Th esideeffectoftwogroupswasmildinthewholeprocessoftreatment．Conclusion CombinedtherapywithUDCA is effectiveinimprovingpatientswithcholestasishepaticdiseases，andUDCA hasnoevidentsideeffectinsuchpatients． Keywords：liverdisease；eholestasis；ursodeoxyeholieacid 肝内胆汁淤积症 (intrahepaticc