低氧诱导因子-1α的翻译后化学修饰及其对活性的调控作用.pdfVIP

18 4 Vol. 18, No. 4 2006 8 Chinese Bulletin of Life Sciences Aug., 2006 1004-0374(2006)04-0385-06 -1α ( , 200025) -1(hypoxia inducible factor-1, HIF-1) HIF-1 α HIF-1α HIF-1 - 1 Q501 A The post-translational chemical modification and its regulating effects on the activity of hypoxia inducible factor-1α KANG Xun-Lei, YI Jing* (Department of Cell Biology, Key Laboratory of the Education Ministry for Cell Differentiation and Apoptosis, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China) Abstract: Hypoxia inducible factor-1( HIF-1 ) is an important transcription factor in oxygen homeostasis of the organism. As a protein, its major subunit HIF-1α is subjected to a variety of the post-translational chemical modification, such as ubiquitination, hydroxylation, acetylation, sumolyation, phosphorylation, sulfhydrylation, etc. By these modifications, the stability, cytoplasmic-nuclear trafficing and transcriptional activity of HIF-1α are regulated. Therefore studies in this aspect are helpful in understanding not only HIF-1α as a therapeutic target for the diseases but also the regulation of other similar transcriptional factors. Key words: HIF-1; chemical modification; post-translational modification 2005-12-07 2006-04-30 (05JC14033) (ZDXK2001) (1 97 8 ) ; (1 95 7 ) * 386 [ 1 ] DNA -1(hypoxia inducible factor-1, HIF- (- RCG TG- ) 2 1) HIF-1α (oxy