尼卡地平控制性降压对家犬脊髓诱发电位的影响.docVIP

尼卡地平控制性降压对家犬脊髓诱发电位的影响 第二军医大学附属长海医院麻醉科 200433　 2.江苏淮安第82医院麻醉科　3.本院骨科 侯 炯1 宗林2　 许 华1 李 明3 【摘要】目的：观察尼卡地平控制性降压对家犬脊髓诱发电位的影响，探讨脊柱手术麻醉中尼卡地平控制性降压的优越性。方法：成年杂种犬6只，体重12.0～15.5kg，用2.5%硫贲妥钠行麻醉诱导、气管插管，术中持续静脉注射维持麻醉。股动脉置管监测MAP。以尼卡地平8μg kg-1 min-1持续静脉注射进行控制性降压，降压标准为基础平均动脉压的40%。以日本光电诱发电位监测仪测定脊髓诱发电位。结果：外周血有创动脉压（MABP）平均下降幅度为42.9%，控制性降压后SEP波幅（Asep）(%)及NMEP波幅(%)无显著差异。结论：尼卡地平控制性降压对SCEPs影响较小，可安全用于脊髓手术。 【关键词】尼卡地平 控制性降压 脊髓诱发电位 The Influence of Nicadipine Induced Hypotension to SCEPs in Dogs Hou-Jiong1, Zong-Lin2, Xu-Hua1， Li-Ming3(1、Department of anesthesiology, Changhai hospital of Shanghai, 2、Department of Anesthesiology, The 82th Hosp. of PLA, Jiangsu,Huaian ，3、Department of orthopaedics, ChangHai hospital of Shanghai) 【Abstract】Objective In order to evaluate the superiority of the controlled hypotension with nicadipine in spinal operation ,the effect of nicardipine induced- hypotension on spinal cord evoked potentials (SCEPs)in dogs were investigated. Methods 6 adult mongrel dogs, weighing 12.0 kg to 15.5kg were used. Trachea and femoral artery were intubated after 2.5% thiopentone sodium(1ml/kg, iv) and continuous vein injection of 2.5% thiopentone sodium(1.1ml kg-1 h-1) to maintain anesthesia. Controlled hypotension was applied by continuous iv nicardipine(8μg kg-1 min-1), which was defined as 40% of basal MAP. MAP was monitored and the changes of SCEPs after nicardipine(8μg kg-1 min-1,iv) injection were observed by laser evoked potential montior. Results: Mean arterial blood pressure(MABP) decreased 42.9% by nicadipine, there are no significant difference among amplititude of wave in SEP and NMEP. Conclusion: Nicardipine induced- hypotension only had less influence on SCEPs, which suggests that nicardipine probably can safely applied to spinal operation. 【Keywords】nicardipine Controlled hypotension spinal cord evoked potentials 脊柱外科手术中常采用控制性降压以减少出血而降压后可能会导致脊髓的血流灌注减低，不利于脊髓的保护。本文尼卡地平控制性降压对家犬的影响尼卡地平控制性降压 材料和方法 动物与麻醉 成年杂种家犬6只，体重12.0～15.5kg