S100A8蛋白在炎症中的作用.pdfVIP

生理学报Acta Physiologica Sinica , April 25, 2012, 64(2): 231–237 231 综 述 S100A8蛋白在炎症中的作用 徐玉东，尹磊淼，王宇，魏颖，杨永清* 上海中医药大学，上海市针灸经络研究所，上海 200030 摘 要：S100A8是一种具有保守的EF-hand结构域的低分子量(10.8 kDa)钙结合蛋白，也是S100蛋白家族的重要成员。研究表 明S100A8蛋白功能与包括哮喘在内的许多炎症性病理过程密切相关。S100A8蛋白主要通过对中性粒细胞的趋化作用激活炎 症细胞和炎性因子、结合并活化膜受体晚期糖基化终末产物受体(receptor for advanced glycation end products, RAGE)和Toll样 受体4 (Toll-like receptor 4, TLR4) ，从而介导细胞内的炎症信号转导等途径，在炎症中发挥重要的调节作用。此外，也有研 究显示S100A8蛋白具有抗炎症活性，表明S100A8在不同的病理生理条件下可能发挥更为复杂的生物学调节功能。本文对 S100A8蛋白在炎症中的作用及其分子机制的研究进展作一综述，为哮喘等炎症性疾病的防治提供新思路。 关键词：S100A8；炎症；信号转导；哮喘 中图分类号：R392.1 ；Q71 S100A8 protein in inflammation XU Yu-Dong, YIN Lei-Miao, WANG Yu, WEI Ying, YANG Yong-Qing* Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China Abstract: S100A8, an important member of the S100 protein family, is a low-molecular-weight (10.8 kDa) calcium-binding protein containing conserved EF-hand structural motifs. Previous studies have shown that the biological function of S100A8 protein is associ- ated with a variety of inflammatory diseases, for example asthma. S100A8 protein plays important roles in the regulation of inflamma- tion. It can activate inflammatory cells and cytokines via chemotactic activity for neutrophils, and bind to the receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4), thus mediating intracellular inflammatory signaling transduction. Additionally, recent studies have reported the anti-inflammation activity of S100A8 protein, which indicates that S100A8 may have a more complex function of biological regulation in the different pathophysiological conditions. In this review, we summarized the stud- ies on the functions and molecular mechanisms of S100A8 protein in inflammation, which would propose a novel strategy for the pro- phylaxis and treatment of asthma and other inflammatory disease