超声引导下经直肠前列腺癌穿刺活检PSA及外腺体积研究.DOCVIP

临床医学论文-超声引导下经直肠前列腺癌穿刺活检PSA及外腺体积研究 【摘要】? 目的：探讨超声引导下经直肠前列腺穿刺活检术临床应用的价值及PSA和前列腺外腺体积与前列腺癌病变之间的关系。方法：超声引导下经直肠前列腺穿刺活检320例，观察和统计PSA≤410 μg/L和PSA＞410 μg/L时前列腺癌的检出率；对前列腺癌组和良性病变组两组体积进行统计分析。结果：PSA≤410 μg/L和PSA＞410 μg/L时前列腺癌的检出例数分别为17例和98例，两组前列腺癌的检出率比较差异有统计学意义（P＜0.05）。前列腺体积在前列腺癌和良性病变比较差异无统计学意义（P＞0.05），但外腺体积在两者之间差异有统计学意义（P＜0.05）。结论：前列腺血清特异抗原（PSA）及外腺体积是指导超声引导下经直肠前列腺穿刺活检术筛查的重要指标。 【关键词】? 前列腺癌；经直肠超声引导穿刺；前列腺特异抗原；前列腺外腺体积 ??? [Abstract]?? Objective：To study clinical value of ultrasound-guided biopsy of prostate gland and the relationship between prostatic carcinoma and relevant factors such as PSA and volume of external gland. Methods:320 cases who had underwent ultrasound-guided prostatic biopsy by rectal approach were summarized，of which detection rates of prostatic carcinoma (in different PSA groups, namely PSA≤410 and ＞410 μg/L)were observed, of which the volume of prostate were significant difference（in different groups，namely prostatic carcinoma and benign lesion）. Results：The people of prostatic cancer in PSA≤410 and ＞410 μg/L were 17 and 98 respectively and there were statistical significance in detection rates between two groups (P＜0.05).There were not statistical significance in volume of prostate (P＞0.05), but there were statistical significance in volume of external gland(P＜0.05).Conclusions:Relevant factors of prostatic carcinoma such as PSA and volume of external gland are the important guide for prostatic biopsy. ??? [Key words]?? Prostatic carcinoma；Transrectal Ultrasound-guided biopsy；Specific antigen of prostate；Volume of prostate external gland ??? 前列腺癌是中老年男性常见肿瘤之一，经直肠超声检查(TRUS)引导下前列腺穿刺活检是目前诊断前列腺癌的标准方法[1]。前列腺特异抗原(PSA)、前列腺外腺体积等是筛查前列腺穿刺病例的常用方法,但是其适用价值尚在讨论中[2]。我们回顾2003年6月～2006年3月320例超声引导下经直肠前列腺穿刺活检的诊断资料，探讨了PSA和前列腺外腺体积对筛查前列腺癌穿刺病例的意义。 ??? 1?? 资料与方法 ??? 1.1?? 一般资料?? 超声引导下经直肠列腺穿刺活栓者320例，年龄41～88岁，平均69岁，其中60岁23例（7.19%），60～69岁148例（46.25%），70～79岁117例（36.56%），≥80岁32例（10.00%）。临床直肠指检、超声或MRI探测有可疑结节,或者血清前列腺特异抗原升高（血清PSA＞410 μg/L）的患者，初诊为可疑前列腺癌，均接受了TRUS引导下前列腺10~13点系统穿刺活检术，并且检测血清前列腺特异抗