沙美特罗替卡松粉吸入剂对初入高海拔地区青年脑体-心理生理能力的影响.DOCVIP

临床医学论文-沙美特罗替卡松粉吸入剂对初入高海拔地区青年脑体-心理生理能力的影响 ?????????作者：马广全，崔建华，马月梅，王伟，李彬，马勇，哈振德，高亮 【摘要】? 目的 探讨沙美特罗替卡松粉吸入剂对初入高海拔地区青年脑体-心理生理能力的影响，为促进高原习服提供新的措施，预防和治疗急性高原病。方法 将34名受试者随机分为沙美特罗组(n=18)和对照组(n=16)，自海拔1 400 m 历时5 d 进入5 200 m ，从进入海拔5 200 m 当天开始，沙美特罗组每天早晚各1次吸入沙美特罗替卡松粉1个剂量(沙美特罗100 μg，丙酸氟替卡松200 μg )，连续5 d；对照组用同样的方法吸入少量生理盐水。于吸入沙美特罗替卡松粉吸入剂第5天采用DDX200型电脑多功能心理生理测试仪，进行脑体心理生理能力检测。检测项目包括左右手交叉敲击和缺失记忆的简单测验。结果 沙美特罗组较对照组比较，左右手交叉敲击依次为：总时间均为（10±0）s；总次数：89.96±19.04:75.21±17.12(次)；正确次数：87.19±17.24：73.56±16.93(次)；错误次数：1.38±0.62:2.81±2.21(次)。沙美特罗组较对照组比较，缺失记忆的简单测验结果:总次数均为（17±0）次；错误次数：1.45±0.93:2.56±1.48(次) 。差异均有显著性意义（P＜0.05）。 结论 在高原吸入沙美特罗替卡松粉吸入剂能显著提高移居者的脑体-心理生理功能，可以促进高原习服、预防和治疗急性高原病。 【关键词】? 高海拔；沙美特罗替卡松粉吸入剂；脑体-心理生理功能；高原病 　　Abstract： Objective???? To explore the effect of almeterol and fluticasone propinate powder inhalant on brain-body mentalphysiology capability of young people at high altitudes.Methods???? 34 subjects were randomly divided into two groups, salmeterol group(n=18) and control group(n=16). They entered region at an elevation of 5 200 metres from 1 400 meters in 5 days.Experiment group inhaled one dose salmeterol (100 μg salmeterol and 200 μg fluticasone propionate) and control group inhaled placebo (0.9% sodium chloride) twice daily for 5 consecutive days. Bothhandscross frequency and deplmemory test were done by type DDX200 multifunction psychological machine on the fifth day. Results???? Compared with control group, Bothhandscross frequency in?? experiment group were shown as follow: total numbers 89.96±19.0475.21±17.12;correct numbers87.19±17.2473.56±16.93；wrong numbers 1.38±0.622.81±2.21. Deplmemory test results were shown as follow: wrong numbers1.45±0.932.56±1.48, all had significant difference（P＜0.05）.Conclusion???? Salmeterol can improve mental and physiology capability of high altitude residents, promote high altitude acclimatization, prevent and cure acute high altitude sickness. 　　Key? words： high altitudes; salmeterol and fluticasone propinate powder inhalant;