5--exercise-cardiac资料.pdfVIP

NIH Public Access Author Manuscript Am J Biomed Sci . Author manuscript; available in PMC 2012 February 28. N Published in final edited form as: I H Am J Biomed Sci. 2011 October 1; 3(4): 241–252. doi:10.5099/aj110400241. - P A A u Exercise Training Prevents Coronary Endothelial Dysfunction in t h o Type 2 Diabetic Mice r M a n Sewon Lee, Yoonjung Park, and Cuihua Zhang u s Departments of Internal Medicine, Medical Pharmacology Physiology, and Nutrition and c r Exercise Physiology, Dalton Cardiovascular Research Center, University of Missouri-Columbia, i p MO 65211 t Abstract Type 2 diabetes (T2D) is a leading risk factor for cardiovascular diseases including atherosclerosis and coronary heart disease. Exercise training (ET) is thought to have a beneficial effect on these disorders, but the basis for this effect is not fully understood. Because endothelial dysfunction N plays a key role in the pathological events leading to cardiovascular complications in T2D, we I H hypothesized that the effects of ET will be evidenced by improvements in coronary endothelial - P function. To test this hypothesis, we assessed the effects of ET on vascular function of diabetic A (db/db, Leprdb) mice by evaluating endothelial function of isolated coronary arterioles of wild- A type (WT) and db/db mice with/without ET. Although dilation of vessels to the endothelial- u t h independent vasodilator, sodium nitroprusside was not different between db/db and WT, dilation o to the endothelial-dependent agonist, acetylc