铝碳酸镁联合雷贝拉唑治疗胃食管反流性咽喉炎的疗效观察.pdfVIP

铝碳酸镁联合雷贝拉唑治疗胃食管反流性咽喉炎的疗效观察 ＊ 董道文 （重庆市綦江区中医院，重庆 401420） 中图分类号 R571；R573；R76 文献标志码 A 文章编号 1001-0408（2013）32-3013-03 DOI 10.6039/j.issn. 1001-0408.2013.32.13 摘 要 目的：观察铝碳酸镁联合雷贝拉唑治疗胃食管反流性咽喉炎的临床疗效。方法：选择胃食管反流性咽喉炎患者400例， 按患者就诊日期的单双号均分为观察组和对照组。两组患者均给予常规清咽、利喉、抗感染治疗。观察组患者在此基础上加用铝 碳酸镁1.0g ，tid+ 雷贝拉唑20mg ，bid 。两组疗程均为4～6周。比较两组患者的临床疗效、食管pH ＜4时间的百分比、De Meester 评分及临床症状总分。结果：与治疗前比较，观察组治疗后第一通道、第二通道pH ＜4时间的百分比及De Meester 评分差异均有 统计学意义（P ＜0.01），而对照组差异无统计学意义（P ＞0.05）。治疗后两组间临床症状总分和总有效率比较，观察组均显著优于 对照组，差异有统计学意义（P ＜0.01）。两组患者均未见明显不良反应发生。结论：铝碳酸镁片联合雷贝拉唑治疗胃食管返流性 咽喉炎疗效和安全性较好，且能有效缓解患者的临床症状。 关键词 胃食管反流；咽喉炎；铝碳酸镁片；雷贝拉唑；临床症状评分 Efficacy Observation of Hydrotalcite Combined with Rabeprazole in the Treatment of Gastroesophageal Re- flux Laryngitis DONG Dao-wen （Chongqing Qijiang District Hospital of TCM ，Chongqing 401420，China ） ABSTRACT OBJECTIVE ：To observe the clinical efficacy of hydrotalcite combined with rabeprazole in the treatment of gastro- esophageal reflux laryngitis. METHODS ：400 patients with gastroesophageal reflux laryngitis during Oct. 2008－Oct. 2012 in our hospital were divided into study group and control group according to single or double day. Control group only received convention- al therapy. On the basis of conventional therapy ，study group was additionally given hydrotalcite 1.0 g ，tid combined with rabepra- zole 20 mg ，bid for 4-6 weeks. The clinical efficacies ，the percentage of pH ＜4，De Meester score and clinical symptom score were compared between 2 groups. RESULTS ：The percentage of first channel pH＜4 and second channel pH＜4 and De Meester score in study group had statistical significance before and after treatment （P ＜0.01），and there was no significant difference in con- trol group （P ＞0.05）. After treatment ，clinical symptom scores and total effective rate of study group were significantly better than those of control group ，there was statis