短期应用泮托拉唑对阿司匹林联合氯吡格雷治疗急性ST 段抬高型心肌梗死疗效的影响.pdfVIP

中华临床医师杂志( 电子版)2013 年9 月第7 卷第18 期 Chin J Clinicians(Electronic Edition),September 15,2013,Vol.7,No.18 ·8139 · ·临床论著· 短期应用泮托拉唑对阿司匹林联合氯吡格雷 治疗急性ST 段抬高型心肌梗死疗效的影响 魏鹏 付强 宗斌 白洁 余涛 王标 徐良洁 张倩 【摘要】 目的 探讨短期应用泮托拉唑对阿司匹林联合氯吡格雷治疗急性 ST 段抬高型心肌梗死疗效 的影响。方法 入选我院心内科首次发生症状并住院成功行急诊PCI 治疗的急性ST 段抬高型心肌梗死患者 207 例，按双抗血小板（阿司匹林＋氯吡格雷）治疗时是否联用泮托拉唑将患者分为两组即联用泮托拉唑组 （PPIs 组）以及未联用泮托拉唑组（对照组），观察患者的消化道出血事件以及MACE 事件。结果 消化 道出血事件主要发生在患者入院后1 周内，PPIs 组与对照组比较有统计学差异（P ＜0.05 ）；两组患者MACE 事件的发生率比较无统计学差异（P ＞0.05 ）。结论 短期应用泮托拉唑并没有增加急性 ST 段抬高型心肌 梗死患者MACE 事件的发生率，同时还能降低消化道出血的发生风险，在临床上特别是针对高危人群值得 推广应用。 【关键词】 心肌梗死； 阿司匹林； 泮托拉唑； 氯吡格雷； 主要心脏不良事件 Effect for short-term application of pantoprazole in patients with acute ST-segment elevation myocardial infarction treated by aspirin and clopidogrel WEI Peng, FU Qiang, ZONG Bin, BAI Jie, YU Tao, WANG Biao, XU Liang -jie , ZHANG Qian. Department of Cardiology, Xuzhou Central Hospital , Xuzhou 221009 , China Corresponding author: FU Qiang, Email: fuqiang@ 【Abstract 】 Objective To observe the efficacy of Short-term application of pantoprazole in patients with acute ST-segment elevation myocardial infarction(STEMI) treated by aspirin and clopidogrel. Methods 207 consecutive acute STEMI patients with the first occurrence of symptoms and hospitalization were randomly divided into two groups: combined treatment group(Aspirin＋clopidogrel＋pantoprazole); control group(Aspirin ＋clopidogrel). Observe the gastrointestinal bleeding events and major cardiovascular events(MACE). Results Gastrointestinal bleeding events of both groups mostly occurred in one week, and there were significant differences(P ＜0.05); there were no significant difference between the two groups for incidence of MACE. Conclusion Short-term application of pantoprazole in patients with acute STEMI did not increase the inc