早期康复训练对急性脑梗死患者血清脑源性神经营养因子表达及运动功能的影响[J].pdfVIP

中国康复理论与实践2012 年5 月第18 卷第5 期 Chin J Rehabil Theory Pract, May 2012, Vol. 18, No.5 - 409 - DOI : 10.3969/j.issn. 1006-9771.2012.05.003 ·专题· 早期康复训练对急性脑梗死患者血清脑源性神经营养因子表达及 运动功能的影响① 1a 1b 1a 1a 1c 甄君 ，董杰 ，王雪晴 ，耿建红 ，韩蓉蓉 [摘要] 目的 观察早期康复训练对急性脑梗死患者血清脑源性神经营养因子(BDNF)表达及运动功能的影响。方法 48 例急 性脑梗死患者随机分为康复组(n=24)和对照组(n=24) ，对照组仅采用药物治疗，康复组在此基础上进行早期康复训练。分别于治疗 前后检测两组患者血清BDNF 水平，采用Fugl-Meyer 运动功能评定(FMA)评价各组运动功能。结果 两组患者治疗后血清BDNF 表达及FMA 评分均较治疗前增加(P0.05) ，康复组优于对照组(P0.05) 。结论 早期康复训练有助于促进急性脑梗死患者血清 BDNF 表达，改善运动功能。 [关键词] 脑梗死；康复；脑源性神经营养因子；运动功能 Effect of Early Rehabilitation Training on Serum Brain-derived Neurotrophic Factor Expression and Motor Function in Patients with Acute Cerebral Infarction ZHEN Jun, DONG Jie, WANG Xue-qing, et al. Department of Rehabilitation Medicine, The Fifth Affiliat- ed Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China Abstract: Objective To observe the effects of early rehabilitation training on serum brain-derived neurotrophic factor (BDNF) expres- sion and motor function in patients with acute cerebral infarction. Methods 48 patients with acute cerebral infarction were randomly divided into rehabilitation group (n=24) and control group (n=24). The control group accepted routine medication, while the rehabilitation group ac- cepted early rehabilitation training in addition. They were assessed with Fugl-Meyer Assessment (FMA), and the expression of BDNF in se- rum was detected before and after treatment. Results The expression of BDNF and the score of FMA increased significantly after treatment in both groups (P0.05), but increased more in the rehabilitation group than in the control group (P0.05). Conc