高龄不稳定性心绞痛患者血清胱抑素水平对近期预后的影响①.pdfVIP

中国康复理论与实践2012 年6 月第18 卷第6 期 Chin J Rehabil Theory Pract, Jun 2012, Vol. 18, No. 6 - 577 - DOI : 10.3969/j.issn. 1006-9771.2012.06.023 ·临床研究· 高龄不稳定性心绞痛患者血清胱抑素水平对近期预后的影响① 李铁岭，鲁晓春，彭卫红，范利 [摘要] 目的 探讨血清胱抑素C(Cys C)水平与不稳定心绞痛患者近期预后的关系。方法 采用散色免疫比浊法测定167例不 稳定心绞痛患者血清Cys C 浓度等指标，观察患者24 h 内首次血清Cys C 值， 1.5 mg/L 者入正常组( 102 例) ，≥1.5 mg/L 者入高 Cys C 组(65 例) 。记录住院期间及出院6 个月内主要心血管事件、病死率和再入院率。结果 高Cys C 组患者心血管事件、病死率 2 和再入院率等终点事件高于正常组(χ =4.16, P=0.042) 。结论 血清Cys C 水平与不稳定性心绞痛患者近期预后有密切的关系，血清 CysC 可作为不稳定性心绞痛患者近期心血管事件的预测因子。 [关键词] 不稳定性心绞痛；胱抑素C ；脑钠肽；预后 Impact of Serum Cystatin C Level on Short Term Prognosis in Elderly Patients with Unstable Angina LI Tie-ling, LU Xiao-chun, PENG Wei-hong, et al. Chinese PLA General Hospital, Beijing 100853, China Abstract: Objective To evaluate the impact of serum cystatin C (Cys C) level on short term prognosis in elderly patients with unstable angina (UA). Methods 167 patients with US were involved in this study. The serum Cys C level was measured by immunonephelometric as- say. The patients were divided into normal group (Cys C 1.5 mg/L, n= 102) and high Cys C group (Cys C ≥1.5 mg/L, n=65) according to their baseline of the first Cys C level within 24 hours. The clinical outcomes, including major cardiac events, mortality and readmission dur- ing hospitalization and 6 months in the follow-up period were observed and evaluated. Results The major cardiac events, mortality and read- 2 mission rate were higher in the high Cys C group than in the normal group (χ =4.16, P=0.042). Conclusion The serum of Cys C level is closely related to the short term prognosis of UA, it could be a