神经节苷酯联合高压氧治疗小儿痉挛型脑瘫①.pdfVIP

中国康复理论与实践2013 年3 月第19 卷第3 期 Chin J Rehabil Theory Pract, Mar. 2013, Vol. 19, No.3 - 255 - DOI : 10.3969/j.issn. 1006-9771.2013.03.014 ·临床研究· 神经节苷酯联合高压氧治疗小儿痉挛型脑瘫① 1 1 2 1 林志 ，陈慧 ，李红刚 ，杨芳 [摘要] 目的 探讨神经节苷酯联合高压氧治疗小儿痉挛型脑瘫的临床效果。方法 128例痉挛型脑瘫患儿分为神经节苷酯联 合高压氧治疗的治疗组(n=70)和胞二磷胆碱治疗的对照组(n=58) ，治疗组根椐年龄大小分为6~ 12个月组(n=38)和1~3 岁组(n=32) 。 治疗前后采用Ashworth 量表、功能独立性测量(FIM)进行评定。结果 治疗组治疗后Ashworth 量表、FIM 评分均明显优于对照组 (P0.01) ；治疗组中6~ 12个月组明显优于1~3 岁组(P0.01) 。结论 神经节苷酯联钠联合高压氧治疗能改善痉挛型脑瘫患儿肌张力 与日常生活活动能力。年龄越小，效果越好。 [关键词] 痉挛型脑瘫；神经节苷酯；高压氧；幼儿 Effect of Ganglioside Combined with Hyperbaric Oxygen on Spastic Cerebral Palsy LIN Zhi, CHEN Hui, LI Hong-gang, et al. Pediat- ric Department of Fujian Provincial Hospital, Fuzhou 350001, Fujian, China Abstract: Objective To investigate the effect of combination of ganglioside and hyperbaric oxygen on spastic cerebral palsy. Methods 128 infants with spastic cerebral palsy were divided into treatment group (n=70) and control group (n=58), who received ganglioside and hy- perbaric oxygen or cytidine diphosphate choline. The infants in the treatment group were divided into young group (6~ 12 months, n=38) and old group ( 1~3 years, n=32) according to their age. They were assessed with Ashworth scale and Functional Independence Measure (FIM) before and 3 courses after treatment. Results The scores of Ashworth scale and FIM improved more in the treatment group than in the con- trol group (P0.01) after treatment, as well as in the young group than in the old group (P0.01). Conclusion The combination of ganglio- side and hyperbaric oxygen is effective on spasticity and activities of daily living in infants with spastic cerebral palsy. The younger the in