西酞普兰治疗功能性消化不良的对照研究.DOCVIP

临床医学论文-西酞普兰治疗功能性消化不良的对照研究 【关键词】? 西酞普兰；功能性消化不良；内科治疗 　　【摘要】 目的? 探讨西酞普兰治疗功能性消化不良的治疗效果。方法???? 将42例功能性消化不良患者随机分为对照组20例，给予内科常规治疗；研究组22例,给予内科常规加西酞普兰治疗。疗程8w。治疗前后采用汉密尔顿抑郁量表和焦虑量表评定疗效，副反应量表评定不良反应。 结果　治疗后两组汉密尔顿抑郁量表评分均逐渐下降，减分率逐渐提高，治疗前与治疗8w末比较，差异极显著(P0.01)。研究组第4w末减分率与对照组比较，差异极显著（P0.01），第8w末差异显著（P0.05）。两组汉密尔顿焦虑量表减分率治疗后均逐渐增高，治疗前与治疗8w末减分率比较,差异极显著（P0.01）。研究组第4w末减分率与对照组比较，差异极显著（P0.01）,第8w末差异显著（P0.05）。 结论? 西酞普兰合并内科药物治疗对改善功能性消化不良明显优于内科常规药物。 　　【关键词】 西酞普兰；功能性消化不良；内科治疗 　　A control study of citalopram on patients with functional dyspepsia?? 　　【Abstract】 Objective To explore the efficacy of citalopram in patients with functional dyspepsia.? Methods Fortytwo patients with functional dyspepsia were randomly assigned into control group(n=20) and research group(n=22). Control group received routine medicine treatment; research group did routine medicine combined with the citalopram for 8 weeks. Before and after treatment, efficacies of both the 2 groups were assessed with the Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA), and side effects assessed with the Treatment Emergent Symptom Scale(TESS) . Results After treatment scores of the HAMD in both the 2 groups gradually dropped and rates of scorereducing increased, which showed significant differences from pretreatment (P0.01). Compared with control group, scorereducing rates of the research group were most different at the end of 4th?week(P0.01) and more different at the 8th (P0.05) from the control group. Conclusion Citalopram combined with routine medicine is better than single routine medicine in the treatment of functional dyspepsia. 　　【Keywords】 Citalompram; functional dyspepsia; medical treatment 　　功能性消化不良（FD）实际上就是《中国精神障碍分类与诊断标准》第3 版（CCMD3）神经症中躯体形式障碍的亚型之一。FD通常长期在综合医院内科治疗，但由于该病症具有神经症躯体形式障碍的基本特点，又常伴有焦虑和抑郁等情绪障碍［1］，应用内科一般的常规治疗，往往难以获得满意疗效。为此我们应用西酞普兰合并内科常规药物进行临床治疗观察，现将结果报告如下。 　　1 对象与方法 　　1.1 对象??????????? 　　研究病例为2002年3月～2004年月10月在我院心理科和内科门诊就诊的患者。入组标准：（1）符合CCMD3躯体形式障碍中自主神经紊乱之胃肠道功能紊乱（包括高位和低位）诊断标准；（2）年龄、性别、文化程度不限；（3）病程3mo；(4)排