长期服用尼尔雌醇对绝经后妇女血脂的影响.DOCVIP

临床医学论文-长期服用尼尔雌醇对绝经后妇女血脂的影响 ??????????????????????????????????? 作者：汪昭葵 王敏敏 薛梅 刘晓瑷 【关键词】? 尼尔雌醇 ??? 【摘要】 目的? 探讨长期（5年以上）服用尼二雌醇对绝经后妇女血脂的影响。 方法? 选择绝经≥5年、连续服用尼尔雌醇≥5年的40例妇女作为激素组，另32例未服药妇女为对照组。所有对象在初诊时及随访1年后测定血脂，包括血浆总胆固醇（TC）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、甘油三酯（TG）、载脂蛋白A（Apo-A）、载脂蛋白B（Apo-B）和脂蛋白（a）［Lp（a）］及性激素（血清FSH和E 2 ）。 结果? 两组的性激素差异无显著性。随访1年后，激素组血TC明显降低（P0.05），对照组血HDL-C明显下降（P0.05）;每日服用尼尔雌醇2mg与每日服用4mg的比较，随访1年后服用4mg组血HDL-C明显升高（P0.05）;雌激素替代疗法（ERT）与激素替代疗法（HRT）比较，随访1年后HRT较ERT血TC明显降低（P0.05）。 结论? 长期服用尼尔雌醇对绝经后妇女血脂变化无不利影响。 ??? 关键词? 绝经 激素替代疗法 血脂 ??? Influence of the blood lipid in postmenopausal women taking nylestriol with a long period ??????? 【Abstract】 Objective To study the influence of the blood lipid in postmenopausal women taking nylestriol with a long period（5years）.Methods 72women，at least5years after menopause.40subjects who had been taking nylestriol for5years or longer were served as hormone group，and other32subjects as control group had given nothing.All these subjects were followed up for one year，and determined blood lipid｛include the plasma levels of total cholesterol（TC），triglyceride（TG），high-density lipoprotein cholesterol（HDL-C），low-density lipopro-tein cholesterol（LDL-C），Apolipoprotein-A（Apo-A），Apolipoprotein-B（Apo-B）and lipoprotein（a）〔Lp（a）〕and sexual hormone（FSH，E 2 ）｝.Results No significant difference was found between the two groups in sexual hormone examination.After one-year follow-up，serum TC value significantly decrease in hormone group（P0.05）.We compared the blood lipid value taking different dosage of nylestriol，and found serum HDL-C value of the women，using4mg nylestriol，was significant increase（P0.05）after one-year follow-up.We also com-pared the effect between HRT and ERT，and detected serumTC value of HRTwas significantly lower than ERT（P0.05）.Conclusion There is no disadvantage for blood lipid in postmenopausal women long-time taking nylestriol. ??? Key words postmenopause hormone replacement therapy blood lipid ??? 激素替代疗法（hormone replacement th