复合氨甲蝶呤硫酸钙人工骨缓释剂治疗骨肉瘤的实验研究论文.doc

上海交通大学 2005 级硕士学位论文 THE STUDY OF SUSTAINED-RELEASING METHOTREATE COMBINED CALCIUM SULFATE IN THE TREATMENT OF OSTEOSARCOMA ABSTRCT  Objective  To develop a drug of Sustained-releasing methotrexate  Combined Calcium Sulfate. To investigate the character of drug release of calcium sulfate combined with methotrexate in the circumstance of Tris-buffered natural saline and it’s inhibitory ability on human osteogenic sarcoma cell MG-63．  Methods  The drug particles combined with 20mg methotrexate, 4% in weight  percentage, and were made manually, as the calcium sulfate for the carrier. The mi