血清乳酸脱氢酶血管内皮生长因子对TACE近期疗效的评估.pdfVIP

964 中国肿瘤临床2014年第41卷第15期 ChinJClinOncol2014,Vol.41,N 血清乳酸脱氢酶 血管内皮生长因子对TACE 近期疗效的评估价值 乔彬彬 施昌盛 虞希祥 王舒婷 肖池金 探讨原发性肝癌（PLC）患者血清乳酸脱氢酶（LDH）与血管内皮生长因子（VEGF）对肝动脉化疗栓塞术（TACE） 摘要 目的： 近期疗效的评估价值。 检测70例肝癌患者TACE术前第1天、术后第3天、第7天、第14天及第21天的血清LDH及VEGF表 方法： 达水平。根据mRECIST标准进行术后疗效评估，将完全缓解+部分缓解+疾病稳定的病例归为获益组（n=46），疾病进展者归为无 效组（n=24）。 LDH及VEGF在术后第14天及21天，无效组的表达水平均高于获益组（P0.05），LDH及VEGF在术后第21 结果： 天的百分比变化无效组高于获益组（P0.05）。LDH及VEGF的术后21天百分比变化在ROC曲线中的曲线下面积分别为65.9% 和85.5%；ROC曲线中LDH及VEGF百分比变化的最佳切点对应的约登指数分别为0.272和0.745。 LDH及VEGF的表达水 结论： 平均可用于TACE的近期疗效评估，其表达水平越低或升高越小，TACE的近期疗效越好。 关键词 原发性肝癌 肝动脉化疗栓塞 乳酸脱氢酶 血管内皮生长因子 疗效 doi:10.3969/j.issn.1000-8179 Value of serum lactate dehydrogenase and vascular endothelial growth factor in evaluating short-term efficacy of TACE Binbin QIAO, Changsheng SHI, Xixiang YU, Shuting WANG, Chijin XIAO Correspondence to: Xixiang YU; E-mail: yudsa@126.com Department of Intervention, the Third Affiliated Hospital of Wenzhou Medical University, Ruian 325200, China. Abstract Objective: To investigate the assessed value of serum lactate dehydrogenase (LDH) and vascular endothelial growth factor (VEGF) for short-term efficacy of transcatheter arterial chemoembolization (TACE). Methods: Serum concentrations of LDH and VEGF from 70 patients with primary liver cancer on the 1st day before therapy and the 3rd, 7th, 14th, and 21st day after TACE ther- apy was determined. The benefit group includes complete remission, partial remission, and stable disease, while the invalid group in- cludes only disease progression. Results: The serum levels of LDH and VEGF in the invalid group were significantly higher than those in the benefit group on the