脂蛋白酯酶基因PvuⅡ多态与中国人高脂血症和冠心病的Meta分析.pdfVIP

HEREDITAS (Beijing) 2010 10 , 32(10): 1031―1036 ISSN 0253-9772 研究报告 DOI: 10.3724/SP.J.1005.2010.01031 脂蛋白酯酶基因Pvu Ⅱ多态与中国人高脂血症和冠心病 的Meta分析 崔璐璐, 王敏, 黄青阳 , , 430079 国内多个研究报道了脂蛋白酯酶基因(LPL)Pvu Ⅱ多态(rs285) 与中国人高脂血症和冠心病的关系, 但单 个研究的样本量都较小(119~647), 结果不尽一致。为了全面客观评价LPL 基因Pvu Ⅱ多态在中国人高脂血症和 冠心病发病中的作用, 文章对所有中国人群的研究进行了Meta 分析。共 11 篇文献纳入研究, 其中关于高脂血 症的研究6 项, 包括患者 943 例, 正常对照 1 093 例, 关于冠心病的研究5 项, 包括患者 821 例, 正常对照727 例。入选研究无明显的发表偏倚, 但经同质性检验存在明显的异质性。Meta 分析结果显示LPL Pvu Ⅱ多态的P+ 等位基因增加高脂血症的患病风险(OR=1.36, 95%CI 1.07~1.73, P=0.011), 但与冠心病相关不显著(P=0.755) 。因 此, 文章结果表明LPL 基因Pvu Ⅱ多态与中国人高脂血症易感性相关联, 与冠心病关联不显著。 脂蛋白酯酶; 多态性; 高脂血症; 冠心病; Meta分析 Meta-analysis of LPL Pvu Ⅱ polymorphism with hyperlipoidemia and coronary heart disease in the Chinese population CUI Lu-Lu, WANG Min, HUANG Qing-Yang Hubei Key Lab of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, China Abstract: Multiple studies reported the association of LPL Pvu polymorphism (rs285) with hyperlipoidemia and coro- nary heart disease in the Chinese population; however, the sample sizes of these studies were small (119-647) and the re- sults were not consistent. A Meta-analysis was undertaken to evaluate the role of LPL Pvu polymorphism in hyperli- poidemia and coronary heart disease in Chinese. A total of 11 case-control studies were collected. Among them, 6 studies on hyperlipoidemia contained 943 cases and 1,093 controls, and 5 studies on coronary heart disease contained 821 cases and 727 controls. No significant publication bias was found and significant heterogeneity between