新型抗生素替代品_重组抗菌剂类蛋白的研究.pdfVIP

第40 卷第8 期 东 北 农 业 大 学 学 报 40(8): 117~122 2009 年 8 月 Journal of Northeast Agricultural University Aug. 2009 新型抗生素替代品－重组抗菌剂类蛋白的研究 单安山，马得莹，冯兴军，孙进华 （东北农业大学动物营养研究所，哈尔滨 150030） 摘 要：长期使用抗生素，尤其是人类常用抗生素会导致抗生素在畜产品中残留及细菌耐药性的产生。因 此，生产者们迫切需要一种既有效又有利于环保的新的抗生素替代剂。抗菌肽和细胞因子由于具有多种活性越来 越受到关注。文章主要介绍了抗菌肽和细胞因子重组蛋白表达与抗菌活性等研究进展，这两类重组蛋白有望成为 新的饲料添加剂服务于养殖业。 关键词：抗生素；抗菌肽；细胞因子 中图分类号：R978.1 文献标识码：A 文章编号：1005-9369 （2009）08－0117－06 Study on new kinds of alternatives for antibiotics-recombinant antimi- crobial agents proteins/SHAN Anshan, MA Deying, FENG Xingjun, SUN Jinhua (Institute of Animal Nutrition, Northeast Agricultural University, Harbin, 150030 , China) Abstract: The paper c oncerned that the extensive use of artificial antibiotics was leading to a re- markable increase in antibiotic resistance among pathogens. Thus, the identification of novel innate anti- microbial agents as natural alternatives for antibiotics was considerable interest. Antimicrobial peptides (AMP) and cytokines were such agents that were of interest as potential novel pharmaceutical agents. This paper studied on expression and antimicrobial activity of recombinant antimicrobial peptides and reco- mbinant chicken cytokines were reviewed. Both recombinant proteins are promising targets for use as alternatives to the antibiotics which are currently widely used. Key words: antibiotics; antimicrobial peptide; cytokines 畜禽是众多人畜共患病，如沙门氏菌、禽流感 们迫切需要一种既有效又有利于环保的新方法来控 等病原的携带者，这些病原不仅是造成畜产品污染 制畜禽疾病、改善畜产品品质。 的原因之一，同时也严重威胁人、畜的健康。因 在众多的抗生素替代剂中，抗菌肽和细胞因子 此，保证畜禽健康，最大潜力地发挥其先天性免疫 由于分布广泛、具有广谱抗菌活性、抗病毒和免疫 功能，对维护人、畜健康，提高禽类的生产性能与 增强等作用，并且对机体无毒害、无残