大鼠电针镇痛的个体差异性及其与基础痛阈的关系.pdfVIP

·92 · 中国疼痛医学杂志 Chinese Journal of Pain Medicine 2000 ,6 , (2) 大鼠电针镇痛的个体差异性 及其与基础痛阈的关系 刘苏星 　罗 　非 　沈 　上 　于英心 　韩济生 (北京医科大学神经科学研究所 ,北京 100083) 摘要 　电针镇痛具有个体差异性。我们采用聚类分析的统计学方法, 以 100Hz 电针 ( ) 30 分钟内辐射热甩尾潜伏期 TFL 升高百分数之平均值为指标 ,将 168 例大鼠分为 优针效和劣针效两个群体 ,其针效至少在两天之内保持相对稳定。电针镇痛效果与 基础痛阈呈显著正相关。即优针效鼠的基础痛阈显著高于劣针效鼠。 关键词 　电针镇痛;个体差异性 ;基础痛阈 ;甩尾阈值 THE INDIVID UAL VARIATION OF EL ECTROACUPUNCTURE ANAL GESIA AND THEIR RELATIONSHIP WITH BASAL PAIN THRESHOLD IN RATS L IU SuXing , L UO Fei , SHEN Shang , YU YingXin , HAN JiSheng Neuroscience Research Institute , Beijin g Medical University , Beijin g 100083 　Present address : Department of Physiolo gy , Baotou Medical College , Neimenggu 014010 Abstract 　In the present study , we observed the individual variation of 100 Hz elec troacupuncture ( EA ) induced analgesia in rats. EA analgesia was measured with the mean percentage increase of radiant heat induced tailflick latency within the 30minutes stimulation period. With cluster analysis , 168 rats were allocated into two groups , namely , highresponder and lowresponder. The effect of EA was steady in at least two days. There exists a positive correlation between the analgesic effect of EA and the basal pain threshold. The highresponder rats displayed significantly higher basal pain thresh old than lowresponders. Key words 　Electroacupunctureinduced analgesia ; Individual variation ; Basal pain threshold 　　临床实践与基础研究中均发现 ,不同个 式 ,将不同针效的大鼠分为优针效与劣针效 体的电针镇痛效果有较大差异[1～4 ] 。这种 两群 ,但缺乏统计学的分类依据。本文以正 个体差异性是否能加以客观的描述 ? 其原因 常大鼠为实验对象 ,采用聚类分析的统计学 何在 ? 能否预测 ? 能否使劣针效个体向优针 方法 ,对电针镇痛的个体差异性进行分类 ,并 效转化 ? 一直是我们