DNA interaction networks： an information highway for regulated gene expression in the 3-dimentional space of the nucleus.pdfVIP

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2017-09-02 发布于湖北
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DNA interaction networks： an information highway for regulated gene expression in the 3-dimentional space of the nucleus.pdf

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DNA interaction networks： an information highway for regulated gene expression in the 3-dimentional space of the nucleus.pdf

1318 teractlonsappeartooccurbetweenloci arangeofstatisticaltoolstocalculate polymer．Thefractalmodelappearsto thatare100Kbormoreawayfrom one lhecontactprobabilityofDNA locias makemoresense whichissupported another．A paneloftheseinteractions theufnctionofgenomicdistance．This by 3D distancemeasuredinarecent wasfurtherconfirmedbyconventional analysisfirstconfirmedchromosome FISHsutdy 『10]．Thisconclusionisnow 3CandFISH．someofwhichwerealso territoriesobservedbynumerouschro— ufrthersubstantiatedbycurvefittingof showntobeinduciblebyestrogen． mosomePaimingstudiesbecauseDNA theHi—Cderivedcontactprobabilltyas Interestingly,theauthorsdetected lociwithinthechromosomes(intra— aufnctionofgenomicdistance． twotypesoflong．distanceintra—chro— chromosomeinteractions)alwaysshow Insummary,thegenome．．wideanaly． mosomalinteractions．Besidesduplex agreatcontactprobabilitythanthosein sisoflong．distanceDNA—DNA interac— interactions．whichreflectindividual separatechromosomes(inter-chromo· tionsreportedbythetworecentstudies pairedinteractionsbewt eenwtospecific somalinteractions)，thereforeimplying marksthebeginningofapredictable genomicloci．theyalsoobservedmany thatDNA sequenceswithinindividual newwaveofinvestigationintothephys． complexinteractionsmatinvolvemu1． chromosomesoccupydistinctterritories icalbasisofregulatedgeneexpression． tipleERa—boundDNA loci．suggesting inthenucleus．Bycalculatingthecon- ThedatarevealedbyChiP—PET has thatmanyDNA segmentsare1ooped tactprobabilitywithindifferentregions already suggestedmanyco-regulated intoacommonproteincomplex．These ofsinglechromosomes(currentlyatthe eventsthatarelikelythedriverofrthe findingsthereforesuggestextensive resolutionof1Mb)．theauthorsalso fornlationofsmallglobulesproposedin DNA loopinginthegenomeandcol— recognizedtwogeneralpatternsofchro— thefracta