Natural killer cells go inside: Entosis versus cannibalism.pdfVIP

Natural killer cells go inside: Entosis versus cannibalism.pdf

  1. 1、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。。
  2. 2、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  3. 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  4. 4、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  5. 5、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  6. 6、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  7. 7、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Natural killer cells go inside: Entosis versus cannibalism.pdf

暑@e2l0lR09esBIeaCrBch,,S2(IB0S09,,C)A19S:1。A20I-llr1i3g2ht1s.resewed11001一一06020/9ll;3322.0000@ RESEARCHHIGHLlGHT llu 丽m/ Naturalkillercellsgoinside:Entosisversuscannibalism YoucunQian,YufangShi, KeyLaboratoryofStemCellBiology,InstituteofHealthSciences,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyof Sciences.&ShanghaiJiaotongUniversitySchoolofMedicine,225SouthChongqingRoad,Shanghai200025,China;2Department ofMolecularGenetics,MicrobiologyandImmunoloyg,UMDNJ-RobertWoodJohnsonMedicalSchool,661HoesLane,Piscataway, NJ08854,USA CellResearch(2009)19:1320—1321.doi:10.1038/cr.2009.134;publishedonline3December2009 ’ Theeel1.in—eel1phenomenon js ofNK cellstotumorcellswasreposed rcagentEGTAinhibitscell—eel1conju— rfequentlyobservedintumorsamples morethantwodecadesago 7『1.How. gationorJunctionsandconsequently especiallyinthosehighlymalignant ever,themechanismsoftheprocess NK cellsinternalizationtoutmorcells. ormetastatictumors.Itisbelieved andthefateoftheinternalizedNKcells Ezrin,anactin—bindingprotein,plays thatthroughthismechanism,cancer haveyettobeinvestigated.Here.Wan2 animportantroleintheregulationof cellscouldingestimmunecellssuch efa1.reportedthatinternalizationof actinandcytoskeletonfunctionsf9]. asneutrophilsandlymphocytes,which NK cellsisanactiveprocessandonly Itwasalso showntobeinvolvedin otherwisekilltumorcells.Tumorcells involveslivecells.whichissimilarto membrane.cytoskeletondynamicsand couldalsophagocytoseutmorceUs— a theprocessofentosis,butdifferentrfom inthefomr ationofimmunotogica1syn. phenomenonresemblesautophagicdi— cannibalism .Inentosis.1iveepitheliaI apsebetweenNKceilsandtargettumor gestionofcellularorganellesunderstar- cellsorutmorcellsdetachrfom extra. cells.W henezrinwaskn ockeddown, vation.Thiscell—eat.eel1phenomenon cellul

文档评论(0)

小泥巴 + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档