_赤_2_烷基苯丙二醇胺类化合物的合成及抗心律失常活性.pdfVIP

Journal of China Pharmaceutical University1996,27( 5):261266 261 ()-2- 任　勇　彭司勋　华维一　朱东亚 ( , 210009) ,, ( FA) , FA 21()-2-( 112 )8 , 19 4 ED50(VP) ED50(VT) 11.0, FA ; ; ; Prevost ( uan-Fu base A; FA) , FA [2] , FA ,S I/4D 25 , FA (MM), FA ()- (1) [1] , FA Fig 1. Structure and dominant conformation of FA , 12 - , FA C C , 13 14 , C C FA , C-O , 114.46 , - 0. 3453 , ( ) -, C O nm 2 , 14, C C , ( )-2-( 112) , ()-2-( 19), , 14 C 21 1996-03-01 262 27 1 ,1 MS, MS, HNMR, IR , [5] , [3] N --3-Pre- , a b vost N [6] , KBH4 ,N 112 19 [4] , c d ,,Prevost c d N - c d , Prevost Prevost ,