Relationship between prognosis and angiogenesis, lymphangiogenesis, proliferative cell distribution in gastric cancer.pdfVIP
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Relationship between prognosis and angiogenesis, lymphangiogenesis, proliferative cell distribution in gastric cancer.pdf
lymphangiogenesislproliferativecelldistributionin
gastriccancer
YangkunWang,ChunfangGap,XianweiZhang,JianYin,FulinLi
DepartmentofPathology.The150CentralHospitalofChinesePLA,Luoyang471031,China
Received:14October2009/Revised:27October2009/Accepted:12November2009
Abstract Objective:WeinvestigatedlherelationshipbetweenIymphangjogenesIs,anglogenesIsandcellproliferationin
flastriccancer.Methods:WeobservedthecentraIcancertissuesandtheperitumoraltissuesof75patientswithgastric
carcinomabyimmunohis10chemislrv.UsingD2—40,VEGFR-CandVEGFR一3detectedthemicrolymphaticdensity(MLD),
CD34andCD31detectedthemicrovesseldensity(MVD).TheproliferationofthecellswaslabeledbyKi-67.Results:There
wereafewatresicstreaklymphaticvesselsinlhecentraIcancerlissues,bulinfheperitumoraltissueslymphaticIncreased
anddilated、itappearsadenoidstructure.LMVDinthegastriccentrafarea(33.7±14.7)decreasedsignificantlythanlnfhe
peripheralzone(61.8±22.6:PO.01).Thedifferencesinthedistributionandamouniofmicrovesselsweresimilartolyre。
phaticvessels.ThecentralareaofgastriccancerhasasniaiIamountofthedistributionoffocalKi-67positivetumorcells,
whilearoundlhecentraIarealherewerealargenumberofKi一67positivelumorcells,especiallyInoneIowpowerfieldx1U).
GastriccentraIareaoflheKI_67positivecellsIngastriccentraIarea(49.5%)weresignificantdecreasinglhaninlhecancer
peripheraIzonef73.2%:P0.O5).Conclusion:Themainlydistributionoflheneonatallymphaticvessels,bloodvesselsand
K_|67positivecarcinomaingastriccancerisanteriorborderofcarcinomalissues,especiallyinonelowpowertield【1Ujllne
MLDMVDandKi一67positivecarcinomamightbeanimportantIndexforlheprognos~sofgastriccarcinoma.Ihemorelyre—
phaticmicrovesse1.microvesseIandKi一67positivecarcinomainlheperitumoralIissues,lhepoorerprognosis,viceversa.
Keywords gastrictumor;angiogenesis;lymphangiogenesis;Ki一67;i
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