Relationship between prognosis and angiogenesis, lymphangiogenesis, proliferative cell distribution in gastric cancer.pdfVIP

Relationship between prognosis and angiogenesis, lymphangiogenesis, proliferative cell distribution in gastric cancer.pdf

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Relationship between prognosis and angiogenesis, lymphangiogenesis, proliferative cell distribution in gastric cancer.pdf

lymphangiogenesislproliferativecelldistributionin gastriccancer YangkunWang,ChunfangGap,XianweiZhang,JianYin,FulinLi DepartmentofPathology.The150CentralHospitalofChinesePLA,Luoyang471031,China Received:14October2009/Revised:27October2009/Accepted:12November2009 Abstract Objective:WeinvestigatedlherelationshipbetweenIymphangjogenesIs,anglogenesIsandcellproliferationin flastriccancer.Methods:WeobservedthecentraIcancertissuesandtheperitumoraltissuesof75patientswithgastric carcinomabyimmunohis10chemislrv.UsingD2—40,VEGFR-CandVEGFR一3detectedthemicrolymphaticdensity(MLD), CD34andCD31detectedthemicrovesseldensity(MVD).TheproliferationofthecellswaslabeledbyKi-67.Results:There wereafewatresicstreaklymphaticvesselsinlhecentraIcancerlissues,bulinfheperitumoraltissueslymphaticIncreased anddilated、itappearsadenoidstructure.LMVDinthegastriccentrafarea(33.7±14.7)decreasedsignificantlythanlnfhe peripheralzone(61.8±22.6:PO.01).Thedifferencesinthedistributionandamouniofmicrovesselsweresimilartolyre。 phaticvessels.ThecentralareaofgastriccancerhasasniaiIamountofthedistributionoffocalKi-67positivetumorcells, whilearoundlhecentraIarealherewerealargenumberofKi一67positivelumorcells,especiallyInoneIowpowerfieldx1U). GastriccentraIareaoflheKI_67positivecellsIngastriccentraIarea(49.5%)weresignificantdecreasinglhaninlhecancer peripheraIzonef73.2%:P0.O5).Conclusion:Themainlydistributionoflheneonatallymphaticvessels,bloodvesselsand K_|67positivecarcinomaingastriccancerisanteriorborderofcarcinomalissues,especiallyinonelowpowertield【1Ujllne MLDMVDandKi一67positivecarcinomamightbeanimportantIndexforlheprognos~sofgastriccarcinoma.Ihemorelyre— phaticmicrovesse1.microvesseIandKi一67positivecarcinomainlheperitumoralIissues,lhepoorerprognosis,viceversa. Keywords gastrictumor;angiogenesis;lymphangiogenesis;Ki一67;i

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