肺部良恶性病变组织中泛素和cullin-1表达及临床病理意义(英文).pdfVIP

中南大学学报 (医学版 ) 　2009, 34 (3 ) 　　h ttp : / / xbyx. xys . net 204 J Cent South U niv (M ed S ci) Exp r e ssion of ub iqu it in an d cu ll in 21 an d it s cl in icopa tho log ica l sign if ican ce in b en ign an d a l ignan t le sion s of th e lun g 1 1 2 PEN G Za i ei , WAN G Hu ifang , SHAN Ch angting ( 1. D epa rt en t of E ergen cy, Second X ia ngya H ospita l, Cen tra l Sou th U n ivers ity, Chan gsha 410011; 2. D epa rt en t of R espira t ion, Aff ilia ted H ospita l of J in ing M ed ica l College, J inin g Shan dong 2 72029 , Ch ina ) Ab str ac t : 　O b ject ive　To investiga te the exp re ssion of ub iqu itin and cu llin21 ( cu l21) in ben ign and alignant le sion s of the lung and to de ter ine their clin icop atho lo gical sign ificance. M ethod s　EnV i2 TM son i u noh istoche istry w as u sed to detect the exp ression of ub iqu itin and cu l21 in th e conventional p araffin2e b edded sec tion s fro the sp eci en s of lung cancer ( n = 80 ) and ben ign lesion tissues of the lun g ( n = 2 0) . W e a lso an alyzed th e rela tion of the exp re ssion of ub iqu itin and cu l21 w ith the clin ical stage, d ifferentia tion, and w ith or w ithou t ly pha tic eta stasis. R esu lt s　The po sitive rate s of u biquitin and cul21 we re significan tly h igher in lung cance