狼疮性肾炎中医证候及其与实验室指标和活动积分的相关性研究.pdfVIP

摘 要 mainly the highest 24 hour urinary protein, increased CHO, TG, Scr, and depressed RBC, HGB. All TCM syndrome types presented the imbalance of T Cell Subsets, which presented mainly increased CD3+, CD4+ T cell, depressed CD8+ T cell, inverted CD4+/CD8+ in different degree; this imbalance of T Cell Subsets was significant in toxic heat flourishing syndrome. Conclusion Yin deficiency of liver and kidney syndrome and Yang deficiency of spleen and kidney syndrome were the mainly TCM syndrom e types; deficiency of both Qi and Yin syndrome was the third type; while toxic heat flourishing syndrome was the least type in 205 inpatients. There were correlations between TCM syndrome types and some laboratory examinations, LN activity index. For exam ple, there was the reference significance to syndrome differentiation of TCM in LN patients with hematuria, proteinuria, 24 hour urinary protein, RBC, HGB, CHO, the imbalance of T Cell Subsets and activity index. Key words Lupus Nephritis (LN) ; TCM syndrome type ; laboratory examinations ; activity index ; correlation - 3 - 狼疮性肾炎中医证候及其与实验室指标和活动积分的相关性研究 前 言 系统性红斑狼疮（systemic lupus erythematosus,SLE ）为一病因未明的全身性 自身免疫病，机体产生对自身细胞核、胞浆及胞膜抗原的抗体，导致免疫复合物 介导的炎症病变，是严重危害人类健康的自身免疫性疾病。SLE 存在肾损害者， 一般称之为狼疮性肾炎（lupus nephritis ，LN ）。我国 SLE 患病率约70.4/10 万， 患病人数达百万之多，且病死率高。狼疮性肾炎是系统性红斑狼疮最常见的内脏 [1] 损害，也是临床最主要的继发性肾脏疾病之一。据中山大学统计 ，约80% 的SLE 患者出现肾脏损害的临床表现，如作肾组织病理活检则几乎百分之百的SLE 患者 存在肾脏病理改变。肾脏病变的严重程度直接影响SLE 患者的预后，肾损害和进 行性肾功能衰竭是 SLE 患者的主要死亡原因之一，故狼疮性肾炎的辨证和治疗对 SLE 患者非常重要。 目前临床上治疗SLE 和LN 主要采用糖皮质激素（简称激素）和免疫抑