干细胞治疗糖尿病足与实验研究进展.docVIP

. . 　　 本文档下载自 HYPERLINK / 文库下载网，内容可能不完整，您可以点击以下网址继续阅读或下载：  HYPERLINK /doc/cc9e0650227916888486d794.html /doc/cc9e0650227916888486d794.html 干细胞治疗糖尿病足的实验研究进展 中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(4): 530–539DOI: 10.11844/cjcb.2014.04.0239 干细胞治疗糖尿病足的实验研究进展 郭勇英1,2 高怀林1,3,4* (1河北医科大学研究生学院, 石家庄 050017; 2河北以岭医药研究院, 国家中医药管理局重点研究室(心脑血管络病), 石家庄 050035; 3河北医科大学附属以岭医院, 河北省中医药络病理论指导糖尿病足防治重点研究室, 石家庄 050091; 4河北省络病重点实验室, 石家庄 050035) 摘要 糖尿病足是指因糖尿病血管病变和(或)神经病变及感染等综合因素, 导致慢性进行性波及肢体大、中、微血管, 引起足部疼痛、皮肤深溃疡或肢体坏疽的一种病变, 是糖尿病的严重并发症之一。临床治疗非常棘手, 难以取得令人满意的疗效, 最终导致截肢甚至危及病患生命。因此, 临床上迫切需要找到创伤小、易接受、疗效好的新的治疗方法。干细胞具有高度增殖和分化成为体内各种细胞的潜能, 其可塑性强, 为糖尿病足的治疗带来新前景, 目前是国内外学者研究的热点之一。该文就干细胞移植治疗糖尿病足的实验研究进展作一综述。 关键词 糖尿病足; 干细胞移植; 实验研究 The Progress of Experimental Study on Stem Cell Therapy for Diabetic Foot Guo Yongying1,2, Gao Huailin1,3,4* (1Graduate School of Hebei Medical University, Shijiazhuang 050017, China; 2Yiling Medical Research Institute of Hebei Province, Key Laboratory of State Administration of Traditional Chinese Medicine (cardio-cerebral vascular network d/doc/cc9e0650227916888486d794.htmlisease), Shijiazhuang 050035, China; 3Yiling Hospital of Hebei Medical University, Department of Guidance in Prevention and Treatment of Diabetic Foot on Hebei Province Chinese Medicine Theory of Collateral Disease, Shijiazhuang 050091, China; 4Key Laboratory of Network Disease of Hebei Province, Shijiazhuang 050035, China) Abstract The diabetic foot (DF) is caused by diabetic vascular disease and/or neuropathy and infections as well as other factors, resulting in chronic progressive affected limb, micro vessel, and causing foot pain, skin ulcers or gangrene of limbs in deep. It is one of the serious complications of diabetes, occasionally causing amputa-tion and even death. It is hard to obtain satisfactory effect, and clinical treatment is very difficult. Therefore, there is an urgent need to find a new treatment with fewer traumas, easier delivery, and good curative effect